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Dr Matthew Hoare | Dr Peter Campbell – Understanding Gene Mutations in Chronic Liver Disease
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About this episode
Liver disease is reported to be the third largest cause of premature death in the UK, with 75% of patients being diagnosed too late for any meaningful intervention. Dr Matthew Hoare from the University of Cambridge, and Dr Peter Campbell from the Sanger Institute, lead a team conducting research into the genome changes associated with chronic liver disease to help understand the cause and consequence of these changes.
Original Article Reference
This SciPod is a summary of the papers ‘Somatic mutations and clonal dynamics in healthy and cirrhotic human liver’, and ‘Convergent somatic mutations in metabolism genes in chronic liver disease’ both published in Nature. DOI: https://doi.org/10.1038/s41586-019-1670-9 and DOI: https://doi.org/10.1038/s41586-021-03974-6
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Professor Paige Lacy | Deciphering Novel Cytokine Secretion Mechanisms
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About this episode
Following exposure to injury or infection, the body elicits a counteractive immune response which involves many different cell types and processes. Cytokines are substances secreted by cells which play a pivotal role in the regulation of this response. Professor Paige Lacy and colleagues in the Department of Medicine at the University of Alberta in Edmonton, Canada, have conducted extensive research into the exact mechanisms underpinning the regulation of cytokine release during the immune response with a particular focus on airway inflammatory disorders.
Original Article Reference
This SciPod is a summary of https://doi.org/10.33548/SCIENTIA843
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Dr Ilida Ortega Asencio | Template-driven Electrospinning: A Smart Manufacturing Approach to Treating Skin Injuries
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About this episode
Human skin acts as an important line of defence against the external environment. To preserve this important function, the regeneration of injured skin is critical. Scientists are now able to artificially replicate aspects of the complex microenvironment in which human skin stem cells reside thanks to the technological advances in the field of biomaterial devices. Dr Ilida Ortega Asencio, from the University of Sheffield, UK, and her team have developed a new approach in which electrospun patches with defined microenvironments can be functionalised with key compounds to aid the formation of new blood vessels in injured skin.
Original Article Reference
This SciPod is a summary of the paper ‘Delivery of Bioactive Compounds to Improve Skin Cell Responses on Microfabricated Electrospun Microenvironments’, from the journal Bioengineering. DOI: https://doi.org/10.3390/bioengineering8080105
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Dr Dipak Panigrahy | Chemotherapy- and Carcinogen-induced Cell Debris Initiates Cancer Recurrence
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About this episode
Chemotherapy, one of the mainstays of cancer treatment, can unfortunately act as a double-edged sword. While achieving the intended aim of killing cancerous cells, it also generates an accumulation of cell debris, which in turn, promotes tumour growth by stimulating inflammation in the tumour microenvironment. Dr Dipak Panigrahy and his colleagues from Harvard Medical School, USA, have conducted several studies in mice showing that targeting the tumour cell debris-mediated surge of proinflammatory and protumourigenic factors provides a strategy for enhancing the efficacy of chemotherapy.
Original Article Reference
This SciPod is a summary of DOI: https://doi.org/10.33548/SCIENTIA842
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Toria Herd | Understanding How Adolescents Respond to Trauma
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Original Article Reference
This SciPod is a summary of the paper ‘Individual and Social Risk and Protective Factors as Predictors of Trajectories of Post-traumatic Stress Symptoms in Adolescents’, published in Research on Child and Adolescent Psychopathology. DOI: https://doi.org/10.1007/s10802-022-00960-y
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Dr Kristin Parent | Bacteriophage Hunting: Searching for the Tiny Viruses That Kill Harmful Bacteria
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About this episode
Shigellosis is an infection of the Shigella bacteria with over 164 million cases each year leading to 1.1 million deaths. The ever-increasing antibiotic resistance of the bacteria means we need alternatives or supplements to existing antibiotics. Dr Kristin Parent from Michigan State University is working on exciting, collaborative projects hunting for bacteriophages to be used in novel therapeutics.
Original Article Reference
This video is a summary of https://doi.org/10.33548/SCIENTIA778
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Professor Manoj Sharma | The Multi-theory Model (MTM) of Health Behavior Change: Understanding the Determinants of Breast Cancer Screening
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About this episode
The multi-theory model (MTM) of health behavior change provides a theoretical framework for understanding and promoting health behaviors. Professor Manoj Sharma from the University of Nevada, Las Vegas, the originator of this model, has applied this model to breast cancer and undertaking mammography screening in women from groups underserved in current healthcare. His findings have important theoretical and practical implications.
Original Article Reference
This SciPod is a summary of the paper ‘Using the Multi-Theory Model (MTM) of Health Behavior Change to Explain the Correlates of Mammography Screening among Asian American Women’, published in Pharmacy, DOI: https://doi.org/10.3390/pharmacy9030126
and
‘A multi-theory model based analysis of correlates for initiating and sustaining mammography screening behavior among Hispanic American women in the United States’ published in Health Promotion Perspectives, DOI: https://doi.org/10.34172/hpp.2022.14
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Yuki Fuseya | Exploring Turing Patterns at Atomic Levels
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About this episode
Patterns can be found across the entire natural world – from the spots on a leopard’s coat to stripes in mineral deposits deep underground. Such motifs are better known as Turing patterns – named after the famous mathematician and codebreaker, Alan Turing, who proposed the theory behind them. Turing patterns are often found on large scales, but they become much rarer at smaller scales, with very few known examples at microscopic and atomic scales. Aharon Kapitulnik and Yuki Fuseya have revealed a new atomic-scale Turing pattern, which arises in an atom-thick layer of bismuth atoms.
Original Article Reference
This video is a summary of the paper ‘Nanoscale Turing patterns in a bismuth monolayer’, in Nature Physics. https://doi.org/10.1038/s41567-021-01288-y
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Sarah Leighton | Can Psychiatric Assistance Dogs Help Military Veterans with Posttraumatic Stress Disorder?
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Psychiatric assistance dogs trained to help with mental health symptoms have become increasingly popular as a complementary intervention for posttraumatic stress disorder (PTSD). Sarah Leighton and her colleagues from Purdue University and the University of Arizona in the USA are exploring the effectiveness of psychiatric assistance dog partnerships for military veterans with PTSD.
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Dr Martín Medina-Elizalde | Collapse of the Ancient Maya Civilisation: Aligning History with Geological Analysis
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About this episode
Between 800 and 1000 CE, one of the world’s most advanced ancient civilisations underwent a devastating decline. The collapse of ancient Maya society has widely been attributed to a century-long drought; but so far, there have been few efforts to quantify this event, or to equate scientific findings with historical sources. Through new geological and paleoclimatological analyses, Dr Martín Medina-Elizalde at the University of Massachusetts, Amherst has revealed that the climate changes experienced during the drought followed more complex patterns than previously thought. His team’s discoveries could have important implications for predicting our own society’s future.
Original Article Reference
This video is a summary of https://doi.org/10.33548/SCIENTIA825
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Krti Tallam | The Importance of Estuaries for Predicting Climate Change Impacts in the Oceans
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About this episode
Climate change is threatening the world’s marine ecosystems in myriad ways, due to rising temperatures, ocean acidification, and sea-level rise. Another often-overlooked effect is that warmer temperatures and changing weather patterns can alter the transmission of many marine parasites and infectious diseases. Such diseases don’t just impact their host populations, as cascading effects can disrupt entire ocean food webs. Krti Tallam at Stanford University studies the evolution of marine parasites and diseases, along with the broader implications for marine ecology. In a recent review paper, Tallam focuses on critically important ecosystems within intertidal zones.
Original Article Reference
This video is a summary of review ‘Assessing intertidal parasite dynamics in the Anthropecene’.
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Professor Rafael Ravina-Ripoll – Achieving Sustainable Competitive Advantage in Organisations: Happiness Management
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About this episode
Sustainable Development Goal 12 refers to responsible production and consumption. Professor Rafael Ravina-Ripoll at the University of Cádiz in Spain and his colleagues (Luis Bayardo Tobar-Pesantez, Estela Núñez-Barriopedro and David Almorza-Gomar) have addressed a lack of research and understanding in the literature about how management models based on happiness management can help promote sustainable and ethical development in the COVID-19 era.
Original Article Reference
This SciPod is a summary of the paper ‘Happiness Management: A Culture to Explore From Brand Orientation as a Sign of Responsible and Sustainable Production’, published in the open access journal Frontiers in Psychology. DOI: https://doi.org/10.3389/fpsyg.2021.727845
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Overcoming Challenges and Defining Successful Strategies: Setting up a Vital Biorepository in Sub-Saharan Africa
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Original Article Reference
This SciPod is a summary of the paper ‘PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa’, from Reproductive Health. DOI: https://doi.org/10.1186/s12978-020-0874-7.
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Dr Clara Pelfrey – Dr Linda Scholl | Charting How Research Leads from Discoveries to Improved Health
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Original Article Reference
This SciPod is a summary of the paper ‘A protocol for retrospective translational science case studies of health interventions’, from the Journal of Clinical and Translational Science. DOI: https://doi.org/10.1017/cts.2020.514.
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Professor Derrick Robinson | Using Intrabodies to Induce Cell Death in Trypanosome Parasites
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About this episode
Trypanosomes are single-celled parasites that cause life-threatening diseases in humans, domestic livestock and wild animals. In sub-Saharan Africa, infection with a species called Trypanosoma brucei or T.brucei causes African sleeping sickness, which results in organ failure and eventually fatal coma if left untreated. There are limited diagnostic tests and treatments available and much of trypanosome biology remains undiscovered.
Original Article Reference
This video is a summary of ‘Intrabody-Induced Cell Death by Targeting the T. brucei Cytoskeletal Protein TbBILBO1’ published in the journal Microbiology Spectrum. DOI: https://doi.org/10.1128/Spectrum.00915-21
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Dr Tie-Cheng Guo – Professor Li You | Viewing Quantum Phases with ‘Time Order’
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Original Article Reference
This SciPod is a summary of the paper ‘Quantum Phases of Time Order in Many-Body Ground States’, from Frontiers in Physics. https://doi.org/10.3389/fphy.2022.847409
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Dr Jozelin María Soto-Alarcón – Dr Diana Xóchitl González-Gómez | The Use of Communal Land by Rural Women in Mexico
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Original Article Reference
This SciPod is a summary of the paper ‘Collective Rural Women Access, Use, and Control Over Communal Land in Mexico: A Post-capitalist Feminist Political Ecology Approach’, published in the open access journal Frontiers. DOI: https://doi.org/10.3389/fsufs.2021.695344
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Caitlin Calio – Ann Higgins-D’Alessandro | Understanding the Experiences of Typically Developing Siblings of People with Autism
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Original Article Reference
“It’s really unexplainable, but everyone here got it:” Analysis of an ASD sibling support group for emerging adults published in Research in Autism Spectrum Disorders. DOI: https://doi.org/10.1016/j.rasd.2021.101857.
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Professor Zygmunt Pizlo | How Fundamentals in Physics Can Explain Perception and Cognition
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Original Article Reference
This SciPod is a summary of the paper ‘Unifying Physics and Psychophysics on the Basis of Symmetry, Least-Action ≈ Simplicity Principle, and Conservation Laws ≈ Veridicality’, published in The American Journal of Psychology.
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Sarah Leighton | Can Assistance Dogs Help Military Veterans with Posttraumatic Stress Disorder?
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Original Article Reference
This SciPod is a summary of the paper ‘Assistance dogs for military veterans with PTSD: A systematic review, meta-analysis, and meta-synthesis’, published in PLoS ONE. DOI: https://doi.org/10.1371/journal.pone.0274960
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Professor Richard Klemke | Targeted Drug Delivery: From Science Fiction to Reality
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Original Article Reference
This SciPod is a summary of https://doi.org/10.33548/SCIENTIA836
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Professor Michael Bukrinsky | Human Immunodeficiency Virus Co-morbidities: How Lipid Homeostasis Alterations Lead to Cardiovascular and Neurological Disorders
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About this episode
Although human immunodeficiency virus (HIV) is still prevalent worldwide, life-saving antiretroviral drugs can now prevent an infection from progressing into acquired immunodeficiency syndrome (AIDS). Nevertheless, people who are HIV-positive are still at increased risk of developing neurological disorders and cardiovascular diseases, known as co-morbidities. Professor Michael Bukrinsky from the George Washington University in Washington DC works to understand the underlying biological mechanisms that lead to these disorders. His research has produced interesting results that demonstrate the role of altered lipid (cholesterol) homeostasis in HIV-infected cells and how this comes to pass.
Original Article Reference
This SciPod is a summary of https://doi.org/10.33548/SCIENTIA836
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Dr Doug Brugge | The Community Assessment of Freeway Exposure and Health Studies: Minimising Exposure to Traffic-related Air Pollution
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People who live close to busy roads and highways are exposed to high levels of traffic-related air pollution. This puts them at risk of significant health difficulties such as high blood pressure, heart attacks and cancer. The Community Assessment of Freeway Exposure and Health Studies led by Dr Doug Brugge from the University of Connecticut represent community-engaged research into the biological impact of high exposure to pollution and importantly, possible solutions to this. This work has shown that high-efficiency particulate arrestance filters are one promising intervention for minimising exposure to pollution and thus improving health.
Original Article Reference
This SciPod is a summary of https://doi.org/10.33548/SCIENTIA837
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Professor Valerii Vinokur – Professor Anna Razumnaya – Professor Igor Lukyanchuk | Reinventing the Capacitor
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Dr Alexandra (Sasha) Pavlova – Professor Paul Sunnucks | Genetic Rescue Saves Species from Extinction
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When a species’ habitat shrinks, its populations decline. Individuals that persist in remaining islands of habitat have no choice but to breed with their relatives, reducing the health and fertility of their offspring. Researchers at Monash University seek to increase genetic diversity in small populations, helping them rebound. They have established ‘genetic rescue’ methods to save many endangered species from extinction, collaborating with wildlife agencies to test solutions.
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Professor Eckehard Schöll | Moritz Gerster – Rewiring the Brain: How a Small-world Network Structure Mimics Spontaneous Synchronisation in Epileptic Seizures
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Original Article Reference
This SciPod is a summary of the paper ‘FitzHugh–Nagumo oscillators on complex networks mimic epileptic-seizure-related synchronization phenomena’, by Moritz Gerster, Rico Berner, Jakub Sawicki, Anna Zakharova, Antonín Škoch, Jaroslav Hlinka, Klaus Lehnertz and Eckehard Schöll, published in Chaos 30, 123130 (2020), https://doi.org/10.1063/5.0021420.
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Dr Alejandro Estrada and Dr Paul A. Garber | The Importance of Indigenous Peoples in Safeguarding Earth’s Primates
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Original Article Reference
This SciPod is a summary of the paper ‘Global importance of indigenous peoples, their lands, and knowledge systems for saving the world’s primates from extinction’ in Science Advances, 2022. https://doi.org/10.1126/sciadv.abn2927
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Dr Evelyn Cooper | Dr Candice Duncan – Improving Agriculture and Geoscience through Educational Initiatives
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Original Article Reference
This SciPod is a summary of https://doi.org/10.33548/SCIENTIA824
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Do European Citizens Accept EU and National Policies Equally?
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Following the global financial crisis of 2007 and 2008, a related economic emergency known as the Euro Crisis spread throughout Europe. To counter this crisis, the EU imposed a series of austerity measures in the worst-hit countries, which fuelled outrage across Europe. However, it is unclear whether citizens were more outraged about these policies because they had been implemented by EU institutions rather than national governments. Professor Sonia Alonso and Professor Ignacio Sánchez-Cuenca recently set out to understand whether the willingness of citizens to accept unpopular policies varies depending on whether they were introduced by their national governments or by EU institutions.
Original Article Reference
This SciPod is a summary of the paper ‘EU intervention vs. national autonomy: do citizens really care?’ in European Politics and Society. doi.org/10.1080/23745118.2020.1865061
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Dr Francesca Ronchi | How Gut Bacteria Influences Brain Health
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Our intestines contain millions of bacteria, known as our microbiota, which secrete compounds and play a key role in keeping us healthy. These bacteria don’t just affect the health of our digestive system, they can influence organs as far away as the brain. Dr Francesca Ronchi at Charité Universitätsmedizin in Berlin is determining the role of the microbiota in the prevention and development of neurological disorders.
Original Article Reference
This SciPod is a summary of the papers ‘The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology’, from Frontiers in Immunology, DOI https://doi.org/10.3389/fimmu.2020.604179, and ‘Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1b production by myeloid cells’, from Nature Communications, DOI: https://doi.org/10.1038/ncomms11541
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