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Prof. Andisheh Dadashi | Unraveling the Mysteries of Human Embryo Metabolism: Insights from Computational Models

Prof. Andisheh Dadashi | Unraveling the Mysteries of Human Embryo Metabolism: Insights from Computational Models

Metabolism is the cornerstone of life, orchestrating the myriad chemical reactions that sustain cells, tissues, and organisms. It drives growth, division, energy production, and cellular maintenance. For scientists, understanding metabolism, particularly during the earliest stages of human development, holds the key to uncovering the origins of various diseases and developmental disorders. However, studying metabolism in human embryos presents formidable challenges due to ethical considerations, their tiny size, and the intricate web of metabolic pathways. In a groundbreaking study, researchers Prof. Andisheh Dadashi and Derek Martinez of the University of New Mexico-Valencia leveraged advanced computational models to shed light on the metabolic processes occurring in human embryos during the critical peri-implantation stage.

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Dr Hosam Alharbi | Estimating Human Age Using Wide View Digital Dental Images

Dr Hosam Alharbi | Estimating Human Age Using Wide View Digital Dental Images

Dental features have been used to estimate age in humans for centuries and may be used with great accuracy in both living and deceased individuals. However, refinement of these techniques to align with modern clinical practice is ongoing. Dr Hosam Alharbi and colleagues at Qassim University in Saudi Arabia have introduced an amended version of an established technique to assess whether dental imaging systems used in modern clinics are suitable for determining human age.

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Dr. Archana Thakur | A Novel Immunotherapy Approach to Treat Solid Tumors

Dr. Archana Thakur | A Novel Immunotherapy Approach to Treat Solid Tumors

Developing therapies to effectively treat cancerous tumors is challenging, due to the hostility of the tumor microenvironment and the potential to unintentionally damage surrounding tissues. Infusions of immune cells can improve immune function and assist the body in fighting disease, although this approach increases the risk of inducing dangerous inflammatory responses. Dr. Archana Thakur and her colleagues at the Universities of Virginia and Pennsylvania have engineered a pioneering immunotherapy system that precisely targets cancerous cells. This new immunotherapy poses minimal risk of adverse reactions, and can be used against a wide range of tumor types.

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Dr. Christopher Buck | Expanding Our Knowledge of Viral Evolution

Dr. Christopher Buck | Expanding Our Knowledge of Viral Evolution

Vitamin D has been studied as a treatment for a large number of diseases and conditions, from cancer to autism to COVID-19. However, its mode of action is not completely understood. Professor Ralf Herwig carries out his research at HG Pharma GmbH (Austria) and Ulster University (UK). His vital work explores the role of vitamin D in the body with a view to unlocking its potential as a treatment for a variety of health conditions involving the immune system.

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Dr Katty Kang | Deciphering the Molecular Origins of Brain Disorders

Dr Katty Kang | Deciphering the Molecular Origins of Brain Disorders

During brain development, anomalies may arise which lead to serious conditions such as epilepsy, triggering seizures and requiring lifelong monitoring and medication. However, the underlying causes and the way in which these defects occur are not completely understood. Dr Katty (Jing-Qiong) Kang and colleagues at Vanderbilt University Medical Centre in the USA have conducted extensive research into the molecular mechanisms associated with developmental brain disorders, with a focus on genetic epilepsy. They propose novel therapeutic targets to effectively manage symptoms and improve clinical outcomes by targeting the root cause.

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Dr Jay Mellies | Using Hungry Microbes to Devour Plastic Pollution

Dr Jay Mellies | Using Hungry Microbes to Devour Plastic Pollution

Plastic pollution is accelerating the destruction of our planet. Discarded plastic can be found in the remotest areas – from the highest mountain tops to the deepest ocean trenches. As many types of plastic take hundreds of years to break down, finding better solutions to the plastic crisis is vital. In recent research, Dr Jay Mellies from Reed College in Oregon examines the ability of microbes to break down mixed-plastic waste.

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Dr Ari Jumpponen | Exploring How Soil Fungi Respond to Drought

Dr Ari Jumpponen | Exploring How Soil Fungi Respond to Drought

Both the frequency and intensity of droughts are forecast to increase in climate change predictions. It is well established that plant communities are sensitive to drought conditions, having implications for agriculture, forestry, and wild habitats. Despite the close association between soil fungi and plants, our understanding of how fungal communities respond to drought remains incomplete. To build this understanding, Dr Ari Jumpponen and his colleagues at Kansas State University used a combination of pure culture- and DNA-based techniques to study soil fungal communities exposed to chronic drought conditions.

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Dr Benjamin Scherlag | Could the Soul Be a Biophysical Reality?

Dr Benjamin Scherlag | Could the Soul Be a Biophysical Reality?

The idea that human beings have souls that leave their body after death is an essential part of most religions and spiritual beliefs. However, this has been very difficult to prove scientifically. Benjamin Scherlag, Ronald Scherlag, Tarun Dasari and Sunny Po at the University of Oklahoma Health Science Centre recently investigated the existence of a soul by conducting a series of scientific studies. They carried out these experiments on a dwarf form of the organism Stentor coeruleus, which is known for its regenerative abilities.

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Dr Gita Kolluru | Dylan Lanser | Dr Larisa Vredevoe – Reproductive Consequences for Tick-Infested Lizards

Dr Gita Kolluru | Dylan Lanser | Dr Larisa Vredevoe – Reproductive Consequences for Tick-Infested Lizards

Each year, male Western fence lizards bob, charge, and battle rivals for a chance to win mates. For many of them, tick infestations threaten to hinder their best efforts by harming the lizards’ health. But just how harmful is tick parasitism for these unfortunate lizard hosts? In their recent research, Dylan Lanser, Dr Larisa Vredevoe, and Dr Gita Kolluru at California Polytechnic State University aimed to answer this question by staging contests between tick-free and tick-infested lizards.

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Dr Rok Kostanjšek | Revealing the Olm Salamander’s Secrets to Advance Biomedical Research

Dr Rok Kostanjšek | Revealing the Olm Salamander’s Secrets to Advance Biomedical Research

The genetic secrets to extraordinary longevity, superhero-like healing and regeneration, and resistance to feeding disorders could be found hidden within the Earth. In underground caves in Dinaric Karst along the Adriatic Sea in the Western Balkans lives a cave salamander, the olm, whose remarkable adaptations mean its genome holds great promise for biomedical research. Dr Rok Kostanjšek and an international team of scientists at the Proteus Genome Research Consortium are tackling the challenge of sequencing the huge olm genome, to provide the basis for studying its unique genetic characteristics.

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Dr Youzhong Guo | Accelerating Our Understanding of Cell Membranes

Dr Youzhong Guo | Accelerating Our Understanding of Cell Membranes

Cell membranes are critical for life. Effectively extracting proteins with naturally associated lipids from cell membranes is necessary for research, but traditional methods may damage these membrane components and limit the accuracy of scientific data. Dr Youzhong Guo at Virginia Commonwealth University has recently developed a revolutionary method for extracting membrane components in the form of Native Cell Membrane Nanoparticles. His team’s exciting work advances our understanding of the structure, function and interactions of membrane proteins and lipids.

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Dr Daniel Suiter – Dr Brian Forschler | Identifying and Preventing Arthropod Encounters in South-eastern USA Homes

Dr Daniel Suiter – Dr Brian Forschler | Identifying and Preventing Arthropod Encounters in South-eastern USA Homes

Arthropods – a group of invertebrates that includes insects, spiders, centipedes and woodlice – are everywhere, and have inhabited this planet for millions of years. They are found in most habitats on Earth – including our gardens and homes. It is in these built environments that a small number are considered a nuisance when sharing our ‘sacred space’. An even smaller number damage buildings or belongings, eat our food – even feed on us – so we label them… pests! Successful management of pest populations requires an understanding of their specific lifestyles and their requirements for food, water, shelter, breeding sites, and favourable temperatures. A team of entomologists at the University of Georgia recently published a guidebook of more than 100 arthropods found in and around homes in the South-eastern USA.

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