About this episode
Liver disease is reported to be the third largest cause of premature death in the UK, with 75% of patients being diagnosed too late for any meaningful intervention. Dr Matthew Hoare from the University of Cambridge, and Dr Peter Campbell from the Sanger Institute, lead a team conducting research into the genome changes associated with chronic liver disease to help understand the cause and consequence of these changes.
Original Article Reference
This SciPod is a summary of the papers ‘Somatic mutations and clonal dynamics in healthy and cirrhotic human liver’, and ‘Convergent somatic mutations in metabolism genes in chronic liver disease’ both published in Nature. DOI: https://doi.org/10.1038/s41586-019-1670-9 and DOI: https://doi.org/10.1038/s41586-021-03974-6
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