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Dr Youzhong Guo | Accelerating Our Understanding of Cell Membranes
Cell membranes are critical for life. Effectively extracting proteins with naturally associated lipids from cell membranes is necessary for research, but traditional methods may damage these membrane components and limit the accuracy of scientific data. Dr Youzhong Guo at Virginia Commonwealth University has recently developed a revolutionary method for extracting membrane components in the form of Native Cell Membrane Nanoparticles. His team’s exciting work advances our understanding of the structure, function and interactions of membrane proteins and lipids.
Clare Jensen | Can Dogs Improve the Mental Well-being of Paediatric Healthcare Professionals?
Paediatric healthcare workers often experience poor mental health and burnout. While specially trained facility dogs have been found to positively impact patient well-being, little research has focused on the benefits for professionals. Clare Jensen and her colleagues from Purdue University and the University of Arizona have undertaken a study demonstrating the positive impact these dogs can have on the mental health of paediatric healthcare workers.
Dr Raymond Palmer | Reducing Chemical Intolerance: Seven Steps to Creating a Clean Air Oasis
Individuals with chemical intolerance may experience an array of symptoms following exposure to toxicants commonly found inside the home. Researchers at UT Health San Antonio, USA, have demonstrated that improving indoor air quality reduces the symptoms of chemical intolerance. One of their most important recommendations is to create a clean air oasis in your own home to ensure the air that you breathe is as free as possible from smoke, chemicals, fragrances, and other common indoor pollutants.
Dr Cynthia K. Thompson | Innovation in Promoting the Recovery of Language after Stroke
Stroke can impair a person’s ability to communicate, resulting in a disorder known as aphasia. To facilitate recovery, scientists must understand how language is processed normally as well as how a stroke may impact the language system in the brain. Dr Cynthia K. Thompson, Ralph and Jean Sundin Professor of Communication Science and Professor of Neurology at Northwestern University, has been researching normal and disordered language for over thirty years. Her focus is on understanding and supporting the recovery of language processes when the brain has been damaged.
Dr Jozina de Graaf | Improving Outcomes Following Lower Limb Amputation
After the amputation of a lower limb, amputees can learn to walk with an artificial replacement for that limb known as a prosthesis. However, this can be challenging due to the loss of somatosensory information such as the perception of touch and pressure. Dr Jozina de Graaf of Aix-Marseille University in France is working with colleagues to find a solution to this lack of somatosensory feedback and improve approaches to rehabilitation for lower limb amputees.
Dr Delphine Muriaux | Shining New Light on Human Immunodeficiency Virus Assembly Mechanisms
People living with human immunodeficiency virus (HIV) now have very effective treatment options to allow them to live long lives but the need for new and improved therapeutics remains. Dr Delphine Muriaux from Le Centre national de la recherche scientifique (CNRS) in Montpellier, France, researches HIV infection and replication utilising advanced state-of-the-art microscopy. This super-resolution imaging has led to new findings on the importance of the HIV-1 Gag proteins and the cellular host co-factor IRSp53, a membrane curving protein, and how they interact with host cell membranes.
Understanding Women’s Sexual Pain from a Psychodynamic Standpoint
Sexual pain, often referred to as vaginismus and dyspareunia, can be a debilitating condition that prevents many women from having penetrative sexual intercourse. While many studies have investigated this disorder, its psychological underpinnings are not yet fully understood. Dr Thula Koops, Christian Wiessner, Professor Johannes Ehrenthal, and Professor Peer Briken at the University Medical Center Hamburg-Eppendorf recently explored some of the psychological dimensions of women’s sexual pain. They conducted this research from the standpoint of psychodynamics, which involves exploring links to childhood experiences and unconscious thoughts and feelings.
Dr Thula Koops – Professor Peer Briken | Real Life Stories: What Causes Sexual Pain Amongst Women?
Limited research has explored the causes of sexual pain and difficulties with intercourse that are experienced by women across the world. Dr Thula Koops and Professor Peer Briken at the University Medical Center Hamburg-Eppendorf have spoken to women experiencing these difficulties and listened to their real stories and thoughts on the origins of their sexual difficulties. Based on these interviews, two main themes emerged. The first links these difficulties to perceived implications of womanhood, while the second focuses on the separation between body and mind in relation to the cause.
Dr Ruth McNair | Lesbian, Gay and Bisexual Homelessness in Australia: Risk and Resilience Factors
There is a strong link between identifying as lesbian, gay or bisexual (LGB) and homelessness. Dr Ruth McNair from the University of Melbourne analysed data investigating risk and resilience factors associated with homelessness according to sexual identity in the Australian population to understand the associations with homelessness and to improve LGB-inclusive homelessness policy and services.
Professor Araceli Díaz Perales | Understanding the Key Role of Mould Spores in Allergic Asthma
Professor Araceli Díaz Perales and her colleagues at the Centre for Plant Biotechnology and Genomics in Spain have made the discovery that mould spores on straw contribute to the increase in allergic asthma reactions. Their work utilising an experimental mouse model of human asthma has important implications for understanding, preventing and treating this common condition.
Daniel Bryant, M.D | Single-Payer Health Care: Financial Implications for a Physician
When considering proposed reforms of the US health care system, some physicians dismiss a single-payer system that would provide health care for all residents, as they believe their incomes would be reduced. In a recent study, Daniel Bryant, M.D., finds that state-based single-payer schemes may actually lead to increased personal incomes for physicians. His work also provides a template for evaluating the financial consequences for physicians within a single-payer health care system.
Professor Manoj Sharma | The Multi-theory Model (MTM) of Health Behavior Change: Understanding Meditation, or ‘Dhyana’
The multi-theory model – or ‘MTM’ – of health behavior change provides a theoretical framework for understanding and promoting health behaviors. Professor Manoj Sharma from the University of Nevada, Las Vegas, has now applied this model to understand the factors that lead people to take up meditation – or ‘dhyana’ – and to maintain this health-related behavior over time. His findings confirm the utility of the MTM in informing behavior change interventions and open up important avenues for future research.
Dr Selina Våge | Modelling Microbes to Understand Ecosystem Dynamics and Infectious Diseases
Our brain’s network structure consists of many interconnected regions, each containing billions of neurons. Many neurons within one region fire electrical signals at the same time, in synchrony, and even neurons across different regions may synchronise. These are known as synchronous clusters. The collective firing of neurons in synchronous clusters is believed to create brainwaves. Brainwave measurements of patients with epilepsy have shown that during seizures, there can be episodes of excessive synchrony. The mechanisms behind these episodes are not well understood.
Professor Eckehard Schöll | Understanding Spontaneous Synchronisation in Epileptic Seizures
Our brain’s network structure consists of many interconnected regions, each containing billions of neurons. Many neurons within one region fire electrical signals at the same time, in synchrony, and even neurons across different regions may synchronise. These are known as synchronous clusters. The collective firing of neurons in synchronous clusters is believed to create brainwaves. Brainwave measurements of patients with epilepsy have shown that during seizures, there can be episodes of excessive synchrony. The mechanisms behind these episodes are not well understood.
Taher Saif | Dr Andrew Holle – Mechanobiology – Exploring the Mechanics of Cell Behaviour
Extracellular biophysical cues have a profound influence on a wide range of cell behaviors, including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal transduction. Cells not only respond to definitively mechanical cues from the extracellular matrix (ECM) but can also sometimes alter the mechanical properties of the matrix and hence influence subsequent matrix-based cues in both physiological and pathological processes. Interactions between cells and materials in vitro can modify cell phenotype and ECM structure, whether intentionally or inadvertently. Interactions between cell and matrix mechanics in vivo are of particular importance in a wide variety of disorders, including cancer, central nervous system injury, fibrotic diseases, and myocardial infarction. Both the in vitro and in vivo effects of this coupling between mechanics and biology hold important implications for clinical applications.
Dr Stella Laletas | How High-conflict Divorce Can Impact Children: Understanding the Perspective of Teachers
Divorce is commonplace but can have negative impacts on the cognitive, emotional, social and psychological development of children. Dr Stella Laletas of the Faculty of Education at Monash University explored the perspectives of teachers working with children in high-conflict divorce contexts. She makes critical recommendations to better support teachers involved in the education of vulnerable children.
Dr Florian Lau | Creating DNA Nanonetworks for Early Disease Detection and Drug Delivery
Nanotechnology offers exciting possibilities for the future of healthcare. Because of the tiny size of nano-devices, they are difficult to design and produce. Self-assembly, which involves taking simple structures and allowing them to combine to form larger, more complex structures, could be a solution to this problem. There are many examples of self-assembly in nature, such as the formation of DNA. Dr Florian Lau and his colleagues at the Institute of Telematics in Lübeck, Germany, research how to alter special building blocks of DNA – which they call ‘tiles’ – in such a way that allows them to self-assemble into ‘nanonetworks’.
Debra Klages | Post-traumatic Growth in Health Professionals Who are Mothers of Adult Children with Schizophrenia
For young people with schizophrenia, their first experience of psychosis is often highly traumatic. Because of the close, nurturing relationships mothers typically have with their children, they too can experience trauma while witnessing their children’s disturbing psychotic episodes. As a result, mothers of adult children with schizophrenia often experience negative impacts on their physical and psychological health. Debra Klages takes a unique perspective by shedding light on how the traumatic experiences of health professionals with dual roles as mothers can lead to personal and professional growth and resilience.
The Multi-theory Model of Health Behavior Change: Understanding Meditation, or ‘Dhyana’ | Professor Manoj Sharma
Meditation is the regular, purposeful practice of becoming aware of one’s bodily sensations, thoughts, or other points of focus. Professor Manoj Sharma, a global health promotion leader and Chair of the Social and Behavioral Health department at the University of Nevada, Las Vegas, wished to test whether a health behavioral model that he developed could explain why adults begin and maintain a meditation practice. While this multi-theory model – or ‘MTM’ – has been applied to many health-related behaviors, two domains are core to the model: initiation of a health behavior and sustenance of this behavior.
Professor John Moses | Shapeshifting Antibiotics – Overcoming Multidrug-Resistant Bacteria
Antibiotic resistance is one of the greatest threats currently facing public health. Professor John Moses, based at Cold Spring Harbor Laboratory, along with a team of international collaborators, has proposed a conceptually unique way to extend the life of clinically used antibiotic drugs.
Dr Maggie O’Haire | Dr Kerri Rodriguez – Service Dogs: Understanding Their Impact on Military Veterans with Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a mental disorder that can develop after experiencing a traumatic event, such as being part of military combat. Dr Maggie O’Haire and Dr Kerri Rodriguez at Purdue University in the USA and their colleagues are working to better understand why and how PTSD service dogs may improve PTSD symptoms among military veterans.
Professor Manoj Sharma | The Multi-theory Model (MTM) of Health Behavior Change: Understanding the Determinants of Breast Cancer Screening
Breast cancer is the most common form of cancer affecting women overall but there are stark differences in breast cancer risk and survival rates between racial and ethnic groups. Breast cancers must be detected at an early stage to ensure timely treatment and the reduction of premature mortality. Professor Manoj Sharma from the School of Public Health at the University of Nevada, USA, is working with colleagues to gain an in-depth understanding of the determinants of undertaking mammogram screening in typically under-represented groups with a view to improving health through behaviour change.
Access to Human Tissue for Collaborative Research
The Collaborative Biorepository for Translational Medicine (CBTM) is based at the University of Cambridge and Addenbrooke’s Hospital in the Cambridge Biomedical Research Centre. Professor Kourosh Saeb-Parsy and the team work to provide reliable access to fresh tissue for collaborative research and to ensure the generously donated tissue has the best chance to make a positive impact.
Dr Alvin Orbaek White | Chemically Recycling Discarded Face Masks into Carbon Nanotubes
Dr Alvin Orbaek White and his colleagues at the Energy Safety Research Institute, based at Swansea University, have shown that chemically recycling discarded face masks to create carbon nanotubes may provide a valuable resource as well as tackle the environmental issue of waste.
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