We can imagine our health as a jigsaw, with each individual piece representing a different aspect of our medical history. These pieces might include blood test results, X-ray images or the notes taken by a doctor as we describe our symptoms. These jigsaw pieces are ultimately recorded and stored in electronic health records (or EHRs). EHRs are a valuable resource, providing an overview of someone’s health and they could have the potential to allow clinicians and researchers to unlock new medical insights. However, there’s a fly in the ointment – not all the pieces in such records always fit together correctly, and they may not completely capture the required information. Some clinical event documentation may not be complete, others do not align with related pieces, and some events are even missing entirely. This data quality problem was tackled by Dr. Hanieh Razzaghi of the Children’s Hospital of Philadelphia, and her colleagues, in their innovative work on the PRESERVE study, a research project exploring chronic kidney disease in children (the PRESERVE study itself was led by Drs. Michelle Denburg and Christopher Forrest). Using EHRs from 15 different hospitals across the United States, the team aimed to understand how various treatments could potentially slow down chronic kidney disease progression. However, initially, they had to make sure that the data they were relying on were accurate, reliable, and suitable for the required complex analyses.

Associate Professor Yassir Mahgoub and his team at Penn State University have uncovered an important link between melancholia – a severe form of depression that often doesn’t respond to treatment – and catatonia – a condition characterized by abnormal movements and associated with schizophrenia. The researchers analyzed case studies involving six patients who had been hospitalized for severe depression. All six patients experienced significant relief from their depressive symptoms by taking lorazepam – a drug typically used to treat catatonia. This discovery reveals a potential new avenue for treating severe, treatment-resistant depression.

The African turquoise killifish, also called Nothobranchius furzeri, is a small, vibrant freshwater species that is making a big splash in aging research. With our aging populations, research into aging and the mechanisms underlying age-related health issues is increasingly important. Scientists in this valuable field prize the killifish because it has a significantly short lifespan at just six to twelve months, making it an ideal model to study age-related diseases. However, as research on this species grows, so does the need for better care and monitoring of their health. In fact, distinguishing between the natural effects of aging and other health issues in these fish, such as pathogens or disease, is crucial in accurately researching age-related phenomena. Moreover, identifying health issues in laboratory fish could help researchers to better maintain health in their fish stocks, improving both experimental results and animal welfare. This is where Dr. Beate Hoppe and her colleagues at the Leibniz Institute on Aging at the Fritz Lipmann Institute, Jena, Germany, step in, pioneering a comprehensive approach to monitoring and managing killifish health that could revolutionize laboratory fish research.

Colorectal cancer is a significant health challenge, and ranks as the second leading cause of cancer-related death and the third most common type of cancer in the United States, among men and women combined. Each year, over 52,000 people in the U.S. die from colorectal cancer, with more than 5,300 deaths occurring in California alone. While early detection of colorectal cancer through screening can significantly reduce both its incidence and mortality, ensuring that screening programs remain effective and sustainable is no small feat, particularly in the face of uncertain funding. This pressing issue is at the heart of recent research conducted by Dr. Ndukaku Omelu of the California Department of Public Health, and colleagues, who examined the sustainability of colorectal cancer screening strategies implemented through the California Colon Cancer Control Program (or C4P for short), with a particular focus on how these screening programs would fare in the absence of future C4P funding, a program funded by the Centers for Disease Control and Prevention (or CDC for short).

Friction is no fun, and moving our joints freely and without pain requires that it is minimised as much as possible. Cartilage is the cushiony, slippery and translucent tissue that lines the ends of our long bones and acts as a lubricating layer within our joints to make their movements smooth and effortless, or at least that’s the theory. For millions of people, ease of joint movement is painfully disrupted by osteoarthritis, a condition that gradually and progressively erodes this protective and functional cartilage layer and leads to pain, stiffness, and reduced mobility. No fun at all. The work of Dr. Marina Danalache of the Department of Orthopedic Surgery at the University Hospital of Tübingen, Germany, and her colleagues sheds new light on how this cartilage breakdown begins and proceeds. Meet matrix metalloproteinase enzymes (or MMPs for short): master regulators of cartilage remodelling, balancing renewal and destruction. In osteoarthritis, this equilibrium shifts – the researchers are decoding their precise roles aiming to unlock targeted interventions and transformative therapies.

Each year, thousands of Australians undergo a procedure to have a cardiac device implanted. These devices, such as pacemakers and defibrillators, help to regulate the heartbeat. Such cardiac implantable electronic devices (or CIEDs for short) are vital for many patients, ensuring that their hearts function properly and preventing life-threatening conditions. However, as Professor William Heddle of Flinders University, Adelaide, Australia, a leading expert in cardiology, points out in a recent Editorial article in the Medical Journal of Australia, these procedures are not without risks, particularly the risk of infection. Prof. Heddle’s Editorial primarily focuses on a recent study conducted in New South Wales, Australia, which sheds light on the factors that increase the risk of CIED-related infections and offers insights into how these risks can be minimized.

Antibiotic resistance may prove to be one of the most significant health challenges we will face this century. As bacteria continue to evolve resistance mechanisms to our arsenal of antibiotics, infections could become a more serious prospect, and medical procedures with a substantial infection risk, such as open surgery, could become unacceptably risky. While antibiotic resistance is often considered to be a human problem, it’s also a growing issue in veterinary medicine. Our pets can also develop infections that are difficult to treat when resistant bacteria are involved. Moreover, as we frequently share a living space with such animals, there is potential for crossover of resistant bacteria to humans. In a far-reaching study, Dr. Robin Temmerman and his colleagues of the executive animal health study center (or CEESA), which is a consortium of animal health companies, shed light on this issue, exploring antibiotic resistance in bacterial urinary tract infections in dogs and cats across Europe. Their findings provide hope and a roadmap for tackling this global problem.