Neurophilic Design, Who We Are and Where We Are – Professor Heidi Zeeman, Griffith University

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https://doi.org/10.26320/SCIENTIA288

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Professor Heidi Zeeman of Griffith University and her collaborators are exploring the innovative research field of neurotrauma and the built environment. They endeavour to understand the experiences of individuals with different brain sensitivities and neurological disabilities and the environments in which they live, work and recover. This work will ultimately inform next generation therapeutic environments, workplace and residential design and the design of public spaces.

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Voice of the Sea, Innovation in Science Communication – Professor Kanesa Duncan Seraphin, University of Hawai’i at Mānoa

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https://doi.org/10.26320/SCIENTIA292

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Communicating science to the public is a difficult undertaking; communicating it in a way that encourages people to change their behaviour is a rare achievement. With her television series Voice of the Sea, Dr Kanesa Duncan Seraphin has produced an innovative program that connects viewers with ocean science and scientists and encourages them to take action to protect our seas.

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An Innovative Approach to Vascular Drug Delivery – Cylerus

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https://doi.org/10.26320/SCIENTIA258

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Prosthetic vascular grafts for dialysis access have a limited lifespan and usefulness due to inflammation, infection and especially blood vessel narrowing at the site of graft implantation. Consequently, patients need repeated surgeries to revise or replace the vascular conduits, which is an expensive and difficult procedure. Cylerus is an innovative company dedicated to developing new methods of drug delivery to prosthetic vascular grafts that has developed a novel medical device called the Drug-Eluting Cuff (DEC). The DEC significantly increases the lifetime of these critical access sites while decreasing costs and the harmful consequences to patients of repeated interventions to maintain graft function (patency) to support life-sustaining hemodialysis.

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Spinal Cord Damage and Emerging Treatments – Dr Jerry Silver, Case Western Reserve University

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https://doi.org/10.33548/SCIENTIA324

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Injuries to the spinal cord can cause permanent paralysis and even lead to death, with little to no hope of regaining lost functions once the trauma has occurred. Dr Jerry Silver and his team at Case Western Reserve University Medical School, USA, have been working to understand why nerves that are damaged through spinal injury don’t regenerate and to identify non-invasive, easy to administer strategies that can promote robust functional recovery.

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Progeny Developing Safeguards Against GPS Outages-Progeny Systems Corporation Charleroi

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https://doi.org/10.26320/SCIENTIA280

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With unprecedented advances in scientific research comes a growing body of data. Accurately interpreting these data is a significant obstacle to an improved understanding of biological systems and their behaviour during disease. To overcome this challenge, Dr Stuart C. Sealfon of the Icahn School of Medicine at Mount Sinai is pioneering innovative approaches that incorporate mathematical modelling and computational prediction to further our understanding of human diseases.

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Orange Innovation, Creating Citrus Disease Resistance – Professor Fred G. Gmitter, Jr, Professor Zhanao Deng, Professor Yi Li

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https://doi.org/10.26320/SCIENTIA286

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Florida’s citrus industry is under threat from Huanglongbing (HLB, or citrus greening disease), a devastating plant disease. A collaboration between the University of Florida and the University of Connecticut aims to develop resistance to HLB in citrus plants, using conventional breeding and cutting-edge CRISPR gene-editing approaches.

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The Incredible Ways of DNA Replication – Professor Michael O’Donnell, The Rockefeller University

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https://doi.org/10.33548/SCIENTIA427

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For over 30 years, Professor Michael O’Donnell, based at the Rockefeller University in New York, has focused on the mechanisms involved in the duplication of genetic material in cells, a process known as DNA replication. Professor O’Donnell’s work spans from the early 1990s, when his team was the first to discover a ring-shaped protein that encircles DNA and clamps the replication machine to DNA. Most recently, the team has been studying the proteins involved in mammalian DNA replication.

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Let There Be Light – Professor Yubin Zhou, Texas A&M University

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https://doi.org/10.33548/SCIENTIA323

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Professor Yubin Zhou, from the Center for Translational Cancer Research at the Texas A&M University Institute of Biosciences & Technology, USA, is developing ways to use light to control cellular function. The researcher and his team are responsible for a series of breakthroughs in this field – known as optogenetics – including the exciting concept of using this method to develop novel ways to treat cancer.

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A Box in the Clouds – Professor Jeffrey C. Hoch, UConn Health

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https://doi.org/10.33548/SCIENTIA322

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Nuclear magnetic resonance (NMR) is without doubt one of the most exciting analytic methods available in biomolecular medicine. Applications include structural biology, metabolic studies, disease diagnosis, and drug discovery. However, the use of NMR can be daunting and complicated, with a multitude of diverse computer programs for analysing the data to choose from. Professor Jeffrey C. Hoch from the University of Connecticut, USA, leads the development of the NMRbox platform, an extensive, freely available, not-for-profit resource aiming to help bring order to this chaos.

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SOONER – Fundamental and Applied Research on Open Online Education in the Netherlands

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https://doi.org/10.33548/SCIENTIA425

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The number of individuals engaging with open online learning is rapidly growing because this form of learning is a flexible means of education that can be adapted to a wide range of different circumstances. Through the SOONER (www.sooner.nu) project, Prof. Dr. Marco Kalz, affiliated to the Heidelberg University of Education and holder of the UNESCO chair of Open Education at the Open University of the Netherlands is working with colleagues at the Open University of the Netherlands, Utrecht University and Maastricht University to gain a better insight into how open online education can be developed in the future. SOONER or the ‘Structuration of Open Online Education in the Netherlands’ is a five-year project financed by the Netherlands Initiative for Educational Research (NRO), the Netherlands Organisation for Scientific Research (NWO) and the Dutch Ministry of Education that is supported by SURF – the collaborative ICT organisation for Dutch education and research.>

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Angler Attitudes, Understanding Atlantic Bluefin Tuna Harvests – Drs Andrew Scheld & William Goldsmith, Virginia Institute of Marine Science

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https://doi.org/10.26320/SCIENTIA274

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Scientists from the Virginia Institute of Marine Science at the College of William & Mary are working to understand what motivates fishermen to target Atlantic bluefin tuna. Collaborating with the fishing community, the team surveyed over 5,000 bluefin tuna fishermen to inform sustainable management efforts and maximise fishermen welfare across the Northeast Atlantic coast of the United States. The team’s work is critical to the conservation of this legendary species.

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Promoting Inclusion in Environmental Policy Development – Professor Dr Jill H. Slinger, Delft University of Technology

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https://doi.org/10.26320/SCIENTIA260

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Responding to global environmental change requires ongoing effort, and long-term success depends heavily upon the input of local communities. Moreover, if diverse viewpoints are included in policy development, then shared solutions and common goals are achieved. Dr Jill Slinger from the Delft University of Technology is committed to this cause. She also brings a wealth of research experience on estuarine and coastal systems to the policy discussion table.

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Engineering Solutions for Improved Vaccines – Calder Biosciences Inc.

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https://doi.org/10.26320/SCIENTIA316

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Designing better vaccines is the end goal for Calder Biosciences Inc., a company that has found a new way to engineer vaccines, ensuring greater stability, prolonging their duration in the body and thereby enhancing protection. Using a natural chemical reaction known as di-tyrosine (DT) crosslinking, Calder is creating safe and potent vaccines against viruses.

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Progeny Developing Safeguards Against GPS Outages – Progeny Systems Corporation

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https://doi.org/10.33548/SCIENTIA437

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Global Navigation Satellite Systems such as GPS are the backbone of many global communications, but they are not immune to failure. Progeny Systems Corporation is dedicated to mitigating such disasters if and when satellite-based communications fail, by developing Earth-based systems that work in comparable ways to synchronised satellite networks. As an alternative to GPS, the company’s technology could provide communicating parties with a crucial yet inexpensive safeguard against future failures.

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Could a Better Understanding of Bacteria Prevent Colorectal Cancer- Professor Jason M. Crawford, Yale University

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https://doi.org/10.26320/SCIENTIA247

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Our digestive system contains trillions of bacterial cells, constituting a highly diverse community of microorganisms living within us that can influence human physiology and cause disease. Dr Jason Crawford at Yale University has extensively researched some of the more harmful bacterial strains, looking at how they promote inflammation and colorectal cancer.

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Improving Electrode Microstructural Dynamics & Battery Performance – Dr Partha P. Mukherjee, Purdue University

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https://doi.org/10.26320/SCIENTIA259

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Whether it be enabling renewable technologies, mobilising electric vehicles, or powering the electronic devices we carry, batteries are essential to modern life. As technology continues to advance, high-quality, long-lasting batteries are needed more than ever. Dr Partha P. Mukherjee and his team at Purdue University hope to gain deeper insight into the complex interactions that happen inside lithium-ion and lithium-sulphur batteries – with the ultimate goal of improving their performance and safety.

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Seeds of STEM – Developing an Innovative Early Childhood Curriculum

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https://doi.org/10.26320/SCIENTIA248

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Introducing science, technology, engineering, and mathematics (STEM) to younger generations has become a key priority for many researchers, educators, and policy makers. Dr Mia Dubosarsky of Worcester Polytechnic Institute (WPI) in Massachusetts, Dr Florencia Anggoro of the College of the Holy Cross (Worcester, MA), Dr Melissa-Sue John of WPI, and colleagues, in partnership with the Worcester Head Start program, have developed an innovative curriculum, Seeds of STEM, aimed at fostering problem-solving skills associated with STEM-related disciplines in preschool children.

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Playing Voice Messages to Improve Hygiene and Health – Dr Stephen Lane, Stargates Inc.

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https://doi.org/10.26320/SCIENTIA253

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Hand hygiene is the most cost-effective approach to preventing the transmission of infectious diseases in hospitals. While there has been much effort towards improving hand hygiene by healthcare workers, patients are seldom targeted. To this end, Dr Stephen Lane, working with Stargates Inc. a small business in Arlington, VA, US, and Johns Hopkins Hospital, of Baltimore, MD, US, has spearheaded efforts to improve patient hand hygiene using a novel approach involving voice reminders, called Hand Hygiene for Patients.

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Wolfspeed & International Femtoscience – Creating a New Generation of Capacitors

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https://doi.org/10.26320/SCIENTIA246

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Capacitors are a vital component in virtually every electronic device we use, and yet, innovations that make them more efficient have been a long time coming. Mr John Fraley and his colleagues at Wolfspeed, A Cree Company, and International Femtoscience are now working on a new generation of capacitors, which they believe could offer vast improvements over current technologies. They have developed a process they hope will greatly improve the energy storage capabilities of capacitors, satisfying what has become a desperate market need.

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Tackling the Obesity Epidemic – Professor Barry Popkin, University of North Carolina

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https://doi.org/10.26320/SCIENTIA250

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Obesity is a growing problem around the world, with many negative consequences for both individuals and societies. Research by Professor Barry M. Popkin and his team at the University of North Carolina aims to help lead us beyond the current obesity epidemic.

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Combatting Cancer – Breakthrough Research Against the Dreaded Disease – Dr Anthony Berdis and Dr Jung-Suk Choi

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https://doi.org/10.26320/SCIENTIA235

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In essence, cancer cannot be ‘cured’, but it can be vigorously treated. However, many of the treatments currently used to combat cancer often cause harmful side-effects, that are sometimes even more dangerous than the disease itself. Dr Anthony Berdis and his team at Cleveland State University look to address this through their research, by designing and developing agents that can make chemotherapeutic drugs more effective at treating different cancer types.

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Diversifying and Retaining STEM Leaders for the Future – Professor Kevin Ahern, Dr. Chelsea Wolk and Stephanie Ramos

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https://doi.org/10.26320/SCIENTIA242

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The growing significance of science, technology, engineering and mathematics (STEM) is not currently being matched by an appropriate level of variation in student demographics. Professor Kevin Ahern, Chelsea Wolk and Stephanie Ramos of Oregon State University are working to facilitate more diversity in STEM subjects and cultivate an environment that helps students persist in their studies and to pursue interests unique to each student.

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Nature’s Vital Signs, Using Bioindicators to Understand Ecosystem Health – Dr Paul Montagna, Texas A&M

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https://doi.org/10.26320/SCIENTIA243

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The 2010 Deepwater Horizon Oil Spill was an environmental disaster in the Gulf of Mexico that may take decades to recover. In the immediate wake of the crisis, scientists began to study the developing effects of the spill. Dr Paul Montagna at Texas A&M, Corpus Christi studies bioindicators from the ecosystems around the Gulf of Mexico. His team’s work focuses on topics that identify the outcomes of human activities. The results of their studies on these local systems are significant for ecosystems worldwide.

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Learning-Based Performance Optimisation of Uncertain Systems – Dr Ali Mesbah, University of California

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https://doi.org/10.26320/SCIENTIA240

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Many systems in nature change in random, unpredictable ways over time. From the motions of microscopic particles in fluids to the daily price of stocks, random processes play a large role in systems we interact with every day. Also, because of our incomplete understanding of the phenomena underlying many non-random systems, the mathematical models we use to describe them are often plagued with random uncertainties. Dr Ali Mesbah at the University of California at Berkeley aims to optimise the performance of random and uncertain systems through learning their behaviour in real time.

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Resilient Cropping Systems for a Sustainable Future – Dr Amélie Gaudin, University of California, Davis

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https://doi.org/10.26320/SCIENTIA230

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Dr Amélie Gaudin at the University of California, Davis explores ways to develop more efficient and resilient cropping systems. Here we take a closer look at just a few of Dr Gaudin’s research projects, which aim to build multifunctional agricultural systems where biodiversity and ecosystem services serve as a basis for improvement. Her comprehensive approach to management offers exciting opportunities to improve resilience and maintain agricultural sustainability in a time of climatic change.

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HTLV-1 The Forgotten Cousin of HIV

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https://doi.org/10.26320/SCIENTIA225

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The catastrophic impact of HIV – human immunodeficiency virus – is well-known worldwide. Not so well known is its distant cousin HTLV-1, human T cell leukaemia virus type 1, which also has the potential to destroy lives. The study of HTLV-1 can shed light on HIV itself. A team at Imperial College London, led by Professor Charles Bangham, has been working to raise awareness of this under-researched virus and to find better treatments for the devastating illnesses that it causes.

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An Integrated Approach To Fighting Inflammatory Bowel Disease – Dr Claudio Fiocchi, Lerner Research Institute, Cleveland Clinic

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https://doi.org/10.26320/SCIENTIA226

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Inflammatory Bowel Disease (IBD) causes significant pain and discomfort to sufferers and severely affects quality of life. Research on IBD focusing on the individual contributing factors has failed to provide truly effective treatment options, and the broader picture has been somewhat neglected. Dr Claudio Fiocchi of the Lerner College of Medicine, Cleveland Clinic, USA, proposes an integrated, holistic approach which holds significant promise for improving both our understanding and treatment of IBD.

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Bile Acids Are Not Just for Digestion – Professors Phillip Hylemon and Huiping Zhou, Virginia Commonwealth University

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https://doi.org/10.26320/SCIENTIA228

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Over the last two decades, bile acids have gone from being thought of as mere helpers during digestion of fats and fat-soluble vitamins, to crucial players in the signalling pathways operating in the liver. Professor Phillip Hylemon and Professor Huiping Zhou, from the Medical College of Virginia, Virginia Commonwealth University, USA, lead two of the main research groups worldwide trying to unveil these pathways and the repercussions of these in terms of disease.

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A Different Tangent to Teaching Trigonometry – Professor James L. McClelland, Stanford University

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https://doi.org/10.26320/SCIENTIA229

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Learning trigonometry is a challenge for many high-school students, impeding their access to careers in science, technology, engineering, and mathematics. Dr James McClelland, a professor of cognitive science at Stanford University, California, has been working to make higher-level mathematics concepts accessible to as many people as possible by assessing the effectiveness of a different approach to learning trigonometry at high-school.

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Understanding Hearing at the Cellular Level – Professor David Furness, Keele University

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https://doi.org/10.26320/SCIENTIA232

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How do we hear and process sound? Professor David Furness at Keele University, UK, is endeavouring to answer this question. By utilising modern microscopical techniques, his team is visualising and identifying the proteins that enable us to convert sound into electrical signals in the hearing pathway.

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