Biology
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Dr Helen Greenwood Hansma | Energy: A Clue to the Origins of Life
Energy is vital for life. It allows important functions to occur in living systems, from the molecular level to the scale of the whole organism. Dr Helen Greenwood Hansma, from the University of California in Santa Barbara, believes that the types of energy used in living cells can provide clues to help us understand the origins of life. In her recent research, she explores how mechanical energy could have driven the processes that gave rise to early life in the absence of chemical energy.
Investigating the Impact of Tannins on Gut Bacteria in Pigs
Weaning is an important time in the pig lifecycle, and changes in diet and environment can lead to unbalanced gut microbiota and pathogen colonisation. Prof. Luciana Rossi, Dr. Matteo Dell’Anno from the University of Milan, and Dr. Maria Luisa Callegari from Catholic University of Sacred Heart, have been investigating the impact on gut bacteria of adding natural compounds known as tannins to piglet food. Importantly, they found that tannins do affect the gut bacteria; with increases seen in bacteria associated with improved growth and gut health, and in particular, those that produce butyrate – a substance with proven health benefits.
Dr Christa Mulder – Understanding How Flowering Plants Respond to Climate Change
A welcome sign of a change in seasons, the year’s first flowers usher in the start of spring. Yet, as the climate warms, some flowers are blooming earlier. Since plants respond to environmental cues, such as temperature, shifts in their annual development has long been considered an effect of climate change. However, significant warming does not always lead to earlier flowering.
Effects of DNA Repair Mechanisms, Oestrogen and Environmental Chemicals on Risk for Breast Cancer | Dr Joseph Jerry
All women are exposed to oestrogen from puberty through menopause. Oestrogen is a natural hormone that is important for breast development and the maintenance of tissues in women but is also linked to an increased risk of breast cancer. As many as 1 in 8 women in the USA will be diagnosed with breast cancer over their lifetime, and the majority of these breast cancers are sensitive to oestrogen. Dr Joseph Jerry and his collaborators at the University of Massachusetts are studying the environmental exposures and genetic differences that alter the consequences of exposure to oestrogens.
Revealing How Ocean Chemistry Controlled Earth’s Ancient Atmosphere and Microbial Evolution | Dr Romain Guilbaud
Important clues buried within ancient rocks that were deposited on the ocean floor around one billion of years ago could help scientists understand the evolutionary history of life on Earth. Dr Romain Guilbaud and an international team of researchers from the UK and China analysed the chemical composition of these rocky sediments from the Huainan Basin in North China. Their findings demonstrate how changes in ocean chemistry occurring between one billion and 800 million years ago strongly limited the production of atmospheric oxygen, which is a necessary prerequisite for the planet to host complex life.
Discovering Unmapped Molecular Targets for Novel Covalent Drugs | Dr Mikail Abbasov
Covalent drugs are molecules that irreversibly bind to specific, targeted sites in the body. They work to inhibit the disease-causing functions of certain proteins by preventing them from interacting with other substances. This is a highly promising field of drug development and the focus of Dr Mikail Abbasov from Cornell University, New York, USA. By creating and utilising new technologies and through collaborative research, Dr Abbasov has mapped novel molecular targets for potential covalent drugs to treat ailments ranging from cancer to autoimmune diseases.
Understanding Why Obesity is a Risk Factor for Cancer | Dr Aliccia Bollig-Fischer
Cancer can be caused by genetic mutations or epigenetic alterations, which are changes to the way DNA is processed, rather than to the DNA itself. These changes can be brought about by obesity, and more specifically, oxidative stress and consequent reactive oxygen species. However, the molecular mechanisms by which this occurs are not well understood. Dr Aliccia Bollig-Fischer from Wayne State University School of Medicine in Michigan is studying these processes and paving the way for the development of novel cancer therapeutics.
Discovery of Neurotrophic Factor-α1 Reveals New Treatment Strategies for Stress-induced Neurodegenerative Diseases and Depression | Dr Y. Peng Loh
Stress produces numerous negative effects on the human body. Lying deep within the brain, one particularly sensitive area is the hippocampus, where chronic exposure to stress hormones can lead to the degeneration and death of neurons. Thankfully, the brain holds defence mechanisms that block some of these negative effects. Deciphering these mechanisms with the aim of better treating neurodegenerative diseases and depression is Dr Y. Peng Loh from the Eunice Kennedy Shriver National Institute of Child Health and Human Development in the USA.
Exploring the Impact of Urbanisation on Soil Microbes | Dr Carl Rosier
Beneath our feet lies one of the most biodiverse habitats imaginable – the soil. These highly active underground microbial communities are vital to ecosystem health; they cycle nutrients, form soil structure, and decompose organic matter, among many other functions. The type of microbes that colonise soil is determined by the local plant community and climatic variables, both of which are rapidly changing due to human activity. In a recent study, Dr Carl Rosier of the University of Delaware has explored how urban development disturbs the environmental cycles that influence the types of microbes found in various soil habitats.
Investigating Fructans to Understand How Plants Can Survive Harsh Environments | Dr José Ordaz-Ortiz
The molecules within plant tissues can tell us about how they can withstand harsh environmental conditions. The Agave tequilana plant, native to Mexico, has a high concentration of fructan molecules throughout its tissues. Alongside his colleagues, Dr José Ordaz-Ortiz at the Center for Research and Advanced Studies of the National Polytechnic Institute in Mexico, combines several powerful analytical techniques to better understand the role that these fructans play in plant biology.
Understanding Sudden Unexpected Infant Death: A Unique Collaboration
When a supposedly healthy infant passes away, it can be hard to understand why. Juan Lavista Ferres (Microsoft), Dr Jan-Marino Ramirez and Dr Tatiana Anderson (both from Seattle Children’s Research Institute), and Professor Edwin Mitchell (University of Auckland), form the core of a novel collaboration to conduct vital and extensive research into the risk factors and mechanisms behind sudden unexpected infant death. This unique collaboration spanning across disciplines, industries and continents, is providing the deeper understanding that is needed to prevent unnecessary infant deaths.
Return of Baird’s Tapir: Blessing or Omen? | Dr LaRoy Brandt – Maggie Singleton
The destruction of jungle and forest habitats is a serious issue threatening species across the globe. Dr LaRoy Brandt and Maggie Singleton of Lincoln Memorial University studied one such threatened species, Baird’s tapir, in Costa Rica. By identifying the tapir’s tracks and deploying remote trail cameras, the team caught rare glimpses of this threatened species, indicating a return of the native population and an increase in their numbers. The question is, however, is this increase a sign of improving habitats or a result of less favourable forces at play?
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