May 10, 2023 | biology, health and medicine

About this episode

Cell membranes are critical for life. Effectively extracting proteins with naturally associated lipids from cell membranes is necessary for research, but traditional methods may damage these membrane components and limit the accuracy of scientific data. Dr Youzhong Guo at Virginia Commonwealth University has recently developed a revolutionary method for extracting membrane components in the form of Native Cell Membrane Nanoparticles. His team’s exciting work advances our understanding of the structure, function and interactions of membrane proteins and lipids. More

Original Article Reference

This Audio is a summary of the papers: ‘Detergent-free systems for structural studies of membrane proteins’, in Biochemical Society Transactions,; ‘A native cell membrane nanoparticles system allows for high-quality functional proteoliposome reconstitution’, in BBA Advances,; and ‘Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis’, in Journal of Visualized Experiments,


For further information, you can connect with Dr Youzhong Guo at

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