People living with human immunodeficiency virus (HIV) now have very effective treatment options to allow them to live long lives but the need for new and improved therapeutics remains. Dr Delphine Muriaux from Le Centre national de la recherche scientifique (CNRS) in Montpellier, France, researches HIV infection and replication utilising advanced state-of-the-art microscopy. This super-resolution imaging has led to new findings on the importance of the HIV-1 Gag proteins and the cellular host co-factor IRSp53, a membrane curving protein, and how they interact with host cell membranes.

There is a strong link between identifying as lesbian, gay or bisexual (LGB) and homelessness. Dr Ruth McNair from the University of Melbourne analysed data investigating risk and resilience factors associated with homelessness according to sexual identity in the Australian population to understand the associations with homelessness and to improve LGB-inclusive homelessness policy and services.

Professor Araceli Díaz Perales and her colleagues at the Centre for Plant Biotechnology and Genomics in Spain have made the discovery that mould spores on straw contribute to the increase in allergic asthma reactions. Their work utilising an experimental mouse model of human asthma has important implications for understanding, preventing and treating this common condition.

Dr Julia Gresky of the German Archaeological Institute and her colleagues examined the frequency and content of accounts of ancient rare diseases in the paleopathological literature. By studying published records over the past 45 years, the researchers provide a long-term perspective on the reporting of rare diseases in archaeological contexts. Despite methodological advancements, their work shows that there is much still to be achieved in this fascinating but understudied field.

In Australia, like in many countries, substance related disorders remain a pressing societal concern. The Australian government recently introduced a new framework to help regulate the quality of care provided and this has been reviewed by Simone Henriksen from the University of the Sunshine Coast. Her analysis highlights a variety of challenges that need to be faced and she provides critical recommendations to support the implementation and sustained usage of the new framework.

An estimated 69 million people worldwide are currently living with traumatic brain injury (TBI). TBI can lead to short- and long-term conditions including sleep disorders, depression, headaches and an increased risk of suicide. TBI has recently been recognised as a chronic condition, although the human factors involved in recovery remain understudied. Working to address this is Professor Barrett S. Caldwell who leads the GROUPER Laboratory at Purdue University, USA.

Increased use of organophosphate chemicals in industry, agriculture and warfare has led to a rising threat of exposure to these neurotoxins in civilian and military populations. Though their danger has been recognised and efforts made to decrease concentrations used, even at low doses these chemicals can still pose significant risks to exposed individuals. Finding effective treatments to counteract the impact of exposure is becoming increasingly important and is the focus of research by Professor Nadezhda Sabeva and Professor Peter Ferchmin at the Universidad Central del Caribe, Puerto Rico.