Across the world, scientists are still trying to answer one of medicine’s most difficult questions: how can we safely and effectively treat brain cancers such as glioma? Despite decades of effort, outcomes for people diagnosed with high-grade glioma remain bleak. Current treatments, including surgery, radiotherapy, and chemotherapy, can slow the disease, but rarely stop it. The GlioLighT consortium, a multidisciplinary European research team funded by the European Innovation Council, has come together to explore a novel approach based on direct light therapy. Being in a very early stage, the project doesn’t promise an immediate cure; instead, it sets out to answer a very fundamental question: can light itself trigger biological processes that might form the basis of a safe and targeted brain tumor therapy?

For centuries, malaria has been one of the deadliest diseases on the planet. Nearly half of the world remains at risk of malaria with more than half a million deaths each year, most of them in children. While some progress has been made in controlling malaria and developing a vaccine, this has stalled recently, with a growing number of deaths since 2019. At the heart of the challenge is the lack of non-invasive and rapid diagnostic technologies for malaria, which are urgently needed, especially in remote or low-resource areas with limited healthcare infrastructure. Happily, a new frontier in medical technology is offering hope, in the form of the Cytophone, a revolutionary device that can detect malaria through the skin without drawing a single drop of blood. This innovation, developed by a team led by Prof. Vladimir Zharov at the University of Arkansas for Medical Sciences and licensed to Cytoastra for further commercialization, represents a leap forward not just in malaria diagnostics, but in how we might monitor disease altogether.

In the 20th century, antibiotics transformed medicine. Infections that once killed millions could be cured with a pill or injection. Surgeries became safer, cancer treatments more effective, and advanced medical interventions, such as organ transplants, became possible, all because doctors could rely on these drugs to control infections. Unfortunately, today, that foundation is crumbling. Bacteria are evolving faster than medicine can keep up. Common antibiotics are failing, and infections that were once easily treatable are becoming deadly again. In 2019 alone, antimicrobial resistance was linked to nearly five million deaths worldwide, making it deadlier than HIV or malaria. The economic cost is equally staggering: the World Bank warns of trillions lost in global productivity and millions pushed into poverty if nothing changes. This crisis, caused by antimicrobial resistance, has been described as a “silent pandemic.” Unlike a sudden outbreak, it spreads quietly, making routine medical care slightly more dangerous each year. Yet amid this grim outlook, new research is opening a window of hope. At the forefront of new innovations in this area are Dr. Kai Hilpert of City St George’s, University of London, and his colleagues, who are pioneering an approach that combines biology, chemistry, and artificial intelligence to reinvent how we discover infection-fighting medicines. Their work has been recognised with a prestigious award from the UK’s Biotechnology and Biological Sciences Research Council, BBSRC.

Operating and maintaining highway rest areas across the United States has long posed a costly challenge for state transportation departments, especially amid tightening budgets and rising demand. In a new study, Dr. Kishor Shrestha, associate professor at Washington State University finds that one outsourcing method known as method-based contracting is significantly more cost-effective than its two main alternatives. The results offer transport officials a clearer path forward for running rest areas more efficiently, and could help to preventing costly, potentially dangerous closures in the future.

By now, most of us are familiar with stories of wildlife interacting with the modern world, often with unfortunate consequences. Examples include urban foxes struck by vehicles, bears rummaging through trash, and sea turtles entangled in plastic. But there’s a quieter, often unseen danger that claims hundreds of millions of bird lives each year. This is the common window, a source of light for us, but potentially deadly for unsuspecting birds on the wing. Bird-window collisions (or BWCs for short) are a global phenomenon and a growing conservation concern. Birds in flight often fail to perceive clear or reflective glass as a barrier, leading to fatal crashes into windows, especially on modern buildings. Until recently, tracking the scope of this problem, especially in tropical and subtropical regions, has proven difficult. Traditional monitoring methods require trained observers, time-consuming surveys, and, critically, access to fresh bird carcasses, which can vanish quickly in warm, scavenger-rich environments. But in Taiwan, an innovative approach is offering new hope, and it’s coming from an unexpected place: social media.

Corn is a cornerstone of modern agricultural food production, particularly in North America. Humans have selectively bred such crops over generations to create better yields, improved appearance and flavor and enhanced disease resistance. However, what if we could skip these arduous rounds of selective breeding and improve a crop’s stability and reliability regardless? Deep within the genetic blueprint of every maize kernel, scientists are aiming to achieve just this. In a recent groundbreaking study, Dr. Jon Reinders of Corteva Agriscience and his colleagues have unveiled a powerful new way to create genetically improved corn, not in a lab dish, but inside the plant itself. This new method is faster, cleaner, safer, and could transform how we grow our most essential crops.

Words change their meanings over time, but tracking these changes has traditionally required painstaking manual analysis by linguists. In recent years, researchers have been using computational models to automatically detect when semantic change happens, and how much of a change has occurred. Recent research led by Associate Professor Nina Tahmasebi and her colleagues in the Change is Key! program introduces innovative computational methods for detecting qualitative features of semantic change, opening new possibilities for understanding language evolution at scale.

Recent research from Professor Maryam Mehrnezhad at the Information Security Department, Royal Holloway University of London and a team of researchers reveals widespread privacy, security and regulatory failings in female-oriented health technologies (also known as FemTech). The researchers’ comprehensive analysis demonstrates how current practices leave sensitive health information vulnerable, while highlighting an urgent need for reform across technical, legal and social dimensions of digital healthcare.

In order to operate safely and efficiently, lithium-ion batteries rely on battery management systems to monitor their state and to control their operation. An essential part of this process is modelling battery behaviour under different conditions to predict performance and prevent failures. To do this efficiently, it is crucial to simplify the underlying physical processes, while sacrificing as little accuracy as possible. Through their research, Dr. Luc Raijmakers and colleagues at the Jülich Research Centre, Germany, compare various different approaches to simplifying simulations. Their results could make it easier for battery operators to decide which approach is best suited to their requirements for accuracy and computational efficiency.

Dr Patrick O’Neill of Pfizer, Ireland, and Professor Jie Wu of the National University of Singapore, and their team, have made groundbreaking advancements in the synthesis of 1,2,3-triazole – a key building block in the manufacture of a life-saving antibiotic. Replacing traditional batch processes, they developed a safer, more efficient method using continuous flow chemistry, which addresses potential global supply chain vulnerabilities. This innovative approach eliminates hazardous intermediates, improves reaction safety, and ensures a stable supply of 1,2,3-triazole for global pharmaceutical production.