Dr Hosam Alharbi | Estimating Human Age Using Wide View Digital Dental Images

Dr Hosam Alharbi | Estimating Human Age Using Wide View Digital Dental Images

Dental features have been used to estimate age in humans for centuries and may be used with great accuracy in both living and deceased individuals. However, refinement of these techniques to align with modern clinical practice is ongoing. Dr Hosam Alharbi and colleagues at Qassim University in Saudi Arabia have introduced an amended version of an established technique to assess whether dental imaging systems used in modern clinics are suitable for determining human age.

Professor Eileen Redmond | A Toast to Moderation: Insights on Alcohol and Heart Health

Professor Eileen Redmond | A Toast to Moderation: Insights on Alcohol and Heart Health

Cardiovascular disease remains a leading cause of death globally. Atherosclerosis, the hardening and narrowing of arteries, is the primary underlying cause. The endothelium, a single layer of cells lining blood vessels, plays a crucial role in vascular health and disease. Disrupted endothelial function can lead to serious conditions such as thrombosis and hypertension and facilitates atherosclerotic plaque development. Interestingly, researchers have shown that alcohol has a complex relationship with cardiovascular health, displaying both protective and harmful effects depending on the dose. The work of Professor Eileen Redmond and her team at the University of Rochester Medical Center offers valuable insights into the nuanced role of alcohol in endothelial function.

Dr. Archana Thakur | A Novel Immunotherapy Approach to Treat Solid Tumors

Dr. Archana Thakur | A Novel Immunotherapy Approach to Treat Solid Tumors

Developing therapies to effectively treat cancerous tumors is challenging, due to the hostility of the tumor microenvironment and the potential to unintentionally damage surrounding tissues. Infusions of immune cells can improve immune function and assist the body in fighting disease, although this approach increases the risk of inducing dangerous inflammatory responses. Dr. Archana Thakur and her colleagues at the Universities of Virginia and Pennsylvania have engineered a pioneering immunotherapy system that precisely targets cancerous cells. This new immunotherapy poses minimal risk of adverse reactions, and can be used against a wide range of tumor types.

Dr Eleanor Wilson | Breath by Breath: Decision-Making in the Final Stages of Motor Neurone Disease

Dr Eleanor Wilson | Breath by Breath: Decision-Making in the Final Stages of Motor Neurone Disease

Motor neurone disease is a currently incurable and progressive neurological disorder that severely impacts muscle function. As the disease progresses, individuals with motor neurone disease experience significant difficulties in movement, speech, swallowing, and breathing. Home mechanical ventilation can be used to support breathing and improve the quality of life. However, while this can alleviate symptoms and extend survival, it does not stop disease progression, and patients and caregivers must confront difficult decisions in their treatment journey. In a new UK study, Dr Eleanor Wilson of the University of Nottingham and colleagues have explored end-of-life decision-making in motor neurone disease patients using home mechanical ventilation.

Dr. Christopher Buck | Expanding Our Knowledge of Viral Evolution

Dr. Christopher Buck | Expanding Our Knowledge of Viral Evolution

Vitamin D has been studied as a treatment for a large number of diseases and conditions, from cancer to autism to COVID-19. However, its mode of action is not completely understood. Professor Ralf Herwig carries out his research at HG Pharma GmbH (Austria) and Ulster University (UK). His vital work explores the role of vitamin D in the body with a view to unlocking its potential as a treatment for a variety of health conditions involving the immune system.

Dr. Rebecca Rose | Adjusting Ventilator Settings Could Improve Outcomes for Premature Infants

Dr. Rebecca Rose | Adjusting Ventilator Settings Could Improve Outcomes for Premature Infants

Premature birth puts infants at a greater risk of developing various medical conditions, including a chronic lung disease known as bronchopulmonary dysplasia – or BPD for short. Dr. Rebecca Rose, a neonatologist at Indiana University, recently explored how modulating ventilator settings used for very premature newborns can significantly improve their outcomes.