by admin | Sep 6, 2024 | health and medicine
Phase 3 clinical trials are the most expensive part of drug development, and the most important hurdle to regulatory approval. More than 95% of phase 3 trials in Alzheimer’s disease fail. The main reason is a poor foundation, namely, inadequate or misleading phase 2 trials. Dr. Donald Berry, Founder of Berry Consultants and Founder and Professor of the Department of Biostatistics at the University of Texas MD Anderson Cancer Center, along with his son Dr. Scott Berry, President of Berry Consultants, are committed to turning the tide. Their revolutionary methodology involves adaptive clinical trial design within a Bayesian statistical approach.
by admin | Aug 15, 2024 | health and medicine
Childbirth is a remarkable event that brings joy and new beginnings but also poses significant physical challenges to the mother’s body. One such challenge is the separation of the pubic symphysis, a joint located between the left and right pubic bones. Dr. Kamalini Das of Regions Hospital, Minnesota, and her colleagues conducted a groundbreaking study to investigate pubic symphysis separation in women who delivered vaginally versus those who had cesarean sections. Their research provides important insights into the nature of this physiological change and its development postpartum.
by admin | Aug 5, 2024 | biology, health and medicine
Dental features have been used to estimate age in humans for centuries and may be used with great accuracy in both living and deceased individuals. However, refinement of these techniques to align with modern clinical practice is ongoing. Dr Hosam Alharbi and colleagues at Qassim University in Saudi Arabia have introduced an amended version of an established technique to assess whether dental imaging systems used in modern clinics are suitable for determining human age.
by admin | Jul 31, 2024 | health and medicine
Cardiovascular disease remains a leading cause of death globally. Atherosclerosis, the hardening and narrowing of arteries, is the primary underlying cause. The endothelium, a single layer of cells lining blood vessels, plays a crucial role in vascular health and disease. Disrupted endothelial function can lead to serious conditions such as thrombosis and hypertension and facilitates atherosclerotic plaque development. Interestingly, researchers have shown that alcohol has a complex relationship with cardiovascular health, displaying both protective and harmful effects depending on the dose. The work of Professor Eileen Redmond and her team at the University of Rochester Medical Center offers valuable insights into the nuanced role of alcohol in endothelial function.
by admin | Jul 10, 2024 | biology, health and medicine
Developing therapies to effectively treat cancerous tumors is challenging, due to the hostility of the tumor microenvironment and the potential to unintentionally damage surrounding tissues. Infusions of immune cells can improve immune function and assist the body in fighting disease, although this approach increases the risk of inducing dangerous inflammatory responses. Dr. Archana Thakur and her colleagues at the Universities of Virginia and Pennsylvania have engineered a pioneering immunotherapy system that precisely targets cancerous cells. This new immunotherapy poses minimal risk of adverse reactions, and can be used against a wide range of tumor types.
by admin | Jul 8, 2024 | health and medicine
Motor neurone disease is a currently incurable and progressive neurological disorder that severely impacts muscle function. As the disease progresses, individuals with motor neurone disease experience significant difficulties in movement, speech, swallowing, and breathing. Home mechanical ventilation can be used to support breathing and improve the quality of life. However, while this can alleviate symptoms and extend survival, it does not stop disease progression, and patients and caregivers must confront difficult decisions in their treatment journey. In a new UK study, Dr Eleanor Wilson of the University of Nottingham and colleagues have explored end-of-life decision-making in motor neurone disease patients using home mechanical ventilation.