Audiobook

Nov 15, 2023 | health and medicine

About this episode

Osteoarthritis is a painful and progressive joint disorder that affects hundreds of millions of people worldwide. Typically, the options for treating the condition involve exercise or medication to reduce pain. However, these methods do not target the underlying structural problems in the joints of patients. Recently, researchers have uncovered a genetic susceptibility to osteoarthritis associated with a protein called GDF5, which is involved in skeletal growth and development. Alongside a team of scientists across Europe, Dr Kerstin Kleinschmidt-Doerr at Merck has explored a modified form of the GDF5 protein, named R399E, which showed effects in animal models and in-vitro experiments for treating pain and the underlying structural problems in osteoarthritis. More

Original Article Reference

This Audio is a summary of the paper ‘R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis’, in Arthritis & Rheumatology, doi.org/10.1002/art.42343

Contact

For further information, you can connect with Dr Kerstin Kleinschmidt-Doerr at [email protected]  

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