Nov 15, 2023 | health and medicine

About this episode

Osteoarthritis is a painful and progressive joint disorder that affects hundreds of millions of people worldwide. Typically, the options for treating the condition involve exercise or medication to reduce pain. However, these methods do not target the underlying structural problems in the joints of patients. Recently, researchers have uncovered a genetic susceptibility to osteoarthritis associated with a protein called GDF5, which is involved in skeletal growth and development. Alongside a team of scientists across Europe, Dr Kerstin Kleinschmidt-Doerr at Merck has explored a modified form of the GDF5 protein, named R399E, which showed effects in animal models and in-vitro experiments for treating pain and the underlying structural problems in osteoarthritis. More

Original Article Reference

This Audio is a summary of the paper ‘R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis’, in Arthritis & Rheumatology,


For further information, you can connect with Dr Kerstin Kleinschmidt-Doerr at  

This work is licensed under a Creative Commons Attribution 4.0 International LicenseCreative Commons License

What does this mean?

Share: You can copy and redistribute the material in any medium or format

Adapt: You can change, and build upon the material for any purpose, even commercially.

Credit: You must give appropriate credit, provide a link to the license, and indicate if changes were made.

Increase the impact of your research!

More episodes

Dr Nina Gmeiner | 21st Century Trends in Property Regimes: Progressive Commons

The ownership of goods, including both material objects and immaterial goods such as intellectual property, is defined...

Dr Selina Våge | Modelling Microbes to Understand Ecosystem Dynamics and Infectious Diseases

Our brain’s network structure consists of many interconnected regions, each containing billions of neurons. Many...

Professor Eckehard Schöll | Understanding Spontaneous Synchronisation in Epileptic Seizures

Our brain’s network structure consists of many interconnected regions, each containing billions of neurons. Many...

Taher Saif | Dr Andrew Holle – Mechanobiology – Exploring the Mechanics of Cell Behaviour

Extracellular biophysical cues have a profound influence on a wide range of cell behaviors, including growth,...

Dr Stella Laletas | How High-conflict Divorce Can Impact Children: Understanding the Perspective of Teachers

Divorce is commonplace but can have negative impacts on the cognitive, emotional, social and psychological development...

Professor Samantha Punch | Benefits of Bridge: The Partnership Mindsport

Bridge is a popular card game played socially and competitively by millions of people throughout the world. Each game...