Sugar Monoesters as Absorption Enhancers for Orally-Delivered Large Pharmaceuticals – Professor David J. Brayden, University College Dublin
Original Article Reference
This SciPod is a summary of the paper ‘Permeability-enhancing effects of three laurate-disaccharide monoesters across isolated rat intestinal mucosae’, published with Open Access for readers in the International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2021.120593
About this episode
The lining of the gut acts naturally as a protective barrier to harmful or oversized materials. Many orally-administered drugs consisting of macromolecules or peptides are difficult to deliver because of their poor permeability across the intestine resulting in failure to reach the bloodstream. Patient preference would be to take these types of medicines orally rather than the currently available delivery route of injections. Professor David J. Brayden, at University College Dublin, is dedicated to enhancing the oral delivery of peptides and other macromolecules. His team and collaborators are conducting cutting edge research on the effects of specific sugar-based monoesters as intestinal permeation enhancers.
This work is licensed under a Creative Commons Attribution 4.0 International License.
What does this mean?
Share: You can copy and redistribute the material in any medium or format
Adapt: You can change, and build upon the material for any purpose, even commercially.
Credit: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
Dr Samantha Dolan – Investigating Facilitators and Barriers to Electronic Immunisation Registry Implementation in Tanzania and Zambia
Digital health interventions have the potential to revolutionalise the management of health information. Despite reduced costs and increased accessibility of technology across the world, the implementation of digital health technologies in low- and middle-income countries has been less than optimal. Dr Samantha Dolan at PATH and the University of Washington and her colleagues investigated the perceived facilitators and barriers to electronic immunisation registry implementation in Tanzania and Zambia, and provide important recommendations for future practice.
There are over 3,600 established cell lines from 150 different species that can be used for scientific and medical research. In two recent studies, Dr Ruth MacKinnon and her team from St Vincent’s Hospital in Melbourne used multiple molecular methods to investigate changes in the way the genes are organised in two types of these cells. They demonstrated the importance of using multiple complementary methods and found that these cells can continue to evolve in the laboratory. They also uncovered evidence of a previously unreported process called ‘centromere capture’ which may be involved in the evolution of cancer cells.
In recent years, many researchers have been investigating the associations between wage, education, and productivity, to gather valuable insight that could guide business decision-making. Professor Qiao Wang at Capital University of Economics and Business in Beijing has recently carried out a study specifically exploring the possibility that the motivation and productivity of business managers could be affected by their levels of education.
Weaning is an important time in the pig lifecycle, and changes in diet and environment can lead to unbalanced gut microbiota and pathogen colonisation. Prof. Luciana Rossi, Dr. Matteo Dell’Anno from the University of Milan, and Dr. Maria Luisa Callegari from Catholic University of Sacred Heart, have been investigating the impact on gut bacteria of adding natural compounds known as tannins to piglet food. Importantly, they found that tannins do affect the gut bacteria; with increases seen in bacteria associated with improved growth and gut health, and in particular, those that produce butyrate – a substance with proven health benefits.
Increase the impact of your research
• Good science communication helps people make informed decisions and motivates them to take appropriate and affirmative action.
• Good science communication encourages everyday people to be scientifically literate so that they can analyse the integrity and legitimacy of information.
• Good science communication encourages people into STEM-related fields of study and employment.
• Good public science communication fosters a community around research that includes both members of the public, policymakers and scientists.
• In a recent survey, 75% of people suggested they would prefer to listen to an interesting story than read it.
Step 1 Upload your science paper
Step 2 SciPod script written
Step 3 Voice audio recorded
Step 4 SciPod published