Sugar Monoesters as Absorption Enhancers for Orally-Delivered Large Pharmaceuticals – Professor David J. Brayden, University College Dublin
Original Article Reference
This SciPod is a summary of the paper ‘Permeability-enhancing effects of three laurate-disaccharide monoesters across isolated rat intestinal mucosae’, published with Open Access for readers in the International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2021.120593
About this episode
The lining of the gut acts naturally as a protective barrier to harmful or oversized materials. Many orally-administered drugs consisting of macromolecules or peptides are difficult to deliver because of their poor permeability across the intestine resulting in failure to reach the bloodstream. Patient preference would be to take these types of medicines orally rather than the currently available delivery route of injections. Professor David J. Brayden, at University College Dublin, is dedicated to enhancing the oral delivery of peptides and other macromolecules. His team and collaborators are conducting cutting edge research on the effects of specific sugar-based monoesters as intestinal permeation enhancers.
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