Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement

Nov 25, 2021 | biology, health and medicine, trending

Original Article Reference

This SciPod is a summary of the paper  ‘Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement’

Authored by ‘Raffaella Morini, Matteo Bizzotto, Fabio Perrucci, Fabia Filipello and Michela Matteoli’

Published in the open access journal Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.640937 

About this episode

Synapse elimination is a tightly regulated process, and an aberrant number of synapses both during the early stages of development or later in aging, has been observed in several neurological conditions, including Alzheimer’s disease, schizophrenia or autism. Effective methodological approaches for investigating how supernumerary synapses and apoptotic material are removed from the brain are vital for understanding the underlying mechanisms, and this, in turn, may provide exciting avenues for the development of new treatments. Dr Morini, Dr Filipello and colleagues at Humanitas University and at Washington University in St Louis have recently published a review about the different strategies and tools available to study the role of microglia, the phagocytes of the brain, in neuronal and synaptic substrates phagocytosis.

 

 

 

This work is licensed under a Creative Commons Attribution 4.0 International LicenseCreative Commons License

What does this mean?

Share: You can copy and redistribute the material in any medium or format

Adapt: You can change, and build upon the material for any purpose, even commercially.

Credit: You must give appropriate credit, provide a link to the license, and indicate if changes were made.

Increase the impact of your research

• Good science communication helps people make informed decisions and motivates them to take appropriate and affirmative action.
• Good science communication encourages everyday people to be scientifically literate so that they can analyse the integrity and legitimacy of information.
• Good science communication encourages people into STEM-related fields of study and employment.
• Good public science communication fosters a community around research that includes both members of the public, policymakers and scientists.
• In a recent survey, 75% of people suggested they would prefer to listen to an interesting story than read it.

Step 1 Upload your science paper

Step 2 SciPod script written

Step 3 Voice audio recorded

Step 4 SciPod published