Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement
Original Article Reference
This SciPod is a summary of the paper ‘Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement’
Authored by ‘Raffaella Morini, Matteo Bizzotto, Fabio Perrucci, Fabia Filipello and Michela Matteoli’
Published in the open access journal Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.640937
About this episode
Synapse elimination is a tightly regulated process, and an aberrant number of synapses both during the early stages of development or later in aging, has been observed in several neurological conditions, including Alzheimer’s disease, schizophrenia or autism. Effective methodological approaches for investigating how supernumerary synapses and apoptotic material are removed from the brain are vital for understanding the underlying mechanisms, and this, in turn, may provide exciting avenues for the development of new treatments. Dr Morini, Dr Filipello and colleagues at Humanitas University and at Washington University in St Louis have recently published a review about the different strategies and tools available to study the role of microglia, the phagocytes of the brain, in neuronal and synaptic substrates phagocytosis.
This work is licensed under a Creative Commons Attribution 4.0 International License.
What does this mean?
Share: You can copy and redistribute the material in any medium or format
Adapt: You can change, and build upon the material for any purpose, even commercially.
Credit: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
Plastic pollution is accelerating the destruction of our planet. Discarded plastic can be found in the remotest areas – from the highest mountain tops to the deepest ocean trenches. As many types of plastic take hundreds of years to break down, finding better solutions to the plastic crisis is vital. In recent research, Dr Jay Mellies from Reed College in Oregon examines the ability of microbes to break down mixed-plastic waste.
Both the frequency and intensity of droughts are forecast to increase in climate change predictions. It is well established that plant communities are sensitive to drought conditions, having implications for agriculture, forestry, and wild habitats. Despite the close association between soil fungi and plants, our understanding of how fungal communities respond to drought remains incomplete. To build this understanding, Dr Ari Jumpponen and his colleagues at Kansas State University used a combination of pure culture- and DNA-based techniques to study soil fungal communities exposed to chronic drought conditions.
The idea that human beings have souls that leave their body after death is an essential part of most religions and spiritual beliefs. However, this has been very difficult to prove scientifically. Benjamin Scherlag, Ronald Scherlag, Tarun Dasari and Sunny Po at the University of Oklahoma Health Science Centre recently investigated the existence of a soul by conducting a series of scientific studies. They carried out these experiments on a dwarf form of the organism Stentor coeruleus, which is known for its regenerative abilities.
Dr Gita Kolluru | Dylan Lanser | Dr Larisa Vredevoe – Reproductive Consequences for Tick-Infested Lizards
Each year, male Western fence lizards bob, charge, and battle rivals for a chance to win mates. For many of them, tick infestations threaten to hinder their best efforts by harming the lizards’ health. But just how harmful is tick parasitism for these unfortunate lizard hosts? In their recent research, Dylan Lanser, Dr Larisa Vredevoe, and Dr Gita Kolluru at California Polytechnic State University aimed to answer this question by staging contests between tick-free and tick-infested lizards.
Increase the impact of your research
• Good science communication helps people make informed decisions and motivates them to take appropriate and affirmative action.
• Good science communication encourages everyday people to be scientifically literate so that they can analyse the integrity and legitimacy of information.
• Good science communication encourages people into STEM-related fields of study and employment.
• Good public science communication fosters a community around research that includes both members of the public, policymakers and scientists.
• In a recent survey, 75% of people suggested they would prefer to listen to an interesting story than read it.
Step 1 Upload your science paper
Step 2 SciPod script written
Step 3 Voice audio recorded
Step 4 SciPod published