Dr. Jeddah Marie Vasquez | Blending Biology and Engineering to Repair Damaged Nerves

Dr. Jeddah Marie Vasquez | Blending Biology and Engineering to Repair Damaged Nerves

When a peripheral nerve is badly damaged due to injury, the consequences can be life-changing. Hands that no longer feel heat or cold, muscles that will not respond to the brain’s commands, and pain that lingers for years are all common outcomes. Surgeons can sometimes stitch nerves back together, but when there is a section of nerve missing entirely, repair becomes far more complex. For decades, researchers have been trying to build better bridges for injured nerve axons to cross. A new interdisciplinary research effort led by Dr. Jeddah Marie Vasquez and Dr. Vijay Kumar Kuna of Research Institutes of Sweden, and their collaborators from Umeå University (Associate Professor Paul Kingham) and University College London (Professor James Phillips), bring together polymer chemistry, materials science, and cell biology to rethink what such a bridge could be made of – and how it might one day be tailored to individual patients.

Dr. Huda Makhluf | The Long Shadow: The Science Behind Long COVID

Dr. Huda Makhluf | The Long Shadow: The Science Behind Long COVID

Four years after the first lockdowns and daily case counts faded from headlines, COVID 19 continues to shape lives in quieter but deeply disruptive ways. For millions of people around the world, the virus did not simply end with a negative test. Instead, it left behind a complex and often invisible condition known as long COVID. This lingering illness challenges how medicine understands recovery, chronic disease, and the long reach of viral infections. In a comprehensive review, Dr. Huda Makhluf of the National University in San Diego, and her colleagues, synthesize what scientists currently know about long COVID and what remains frustratingly uncertain.

Prof. Dr. Christopher Gerner | Ulcerative Colitis and the Hidden Logic of Chronic Disease

Prof. Dr. Christopher Gerner | Ulcerative Colitis and the Hidden Logic of Chronic Disease

Ulcerative colitis, often called UC, is a chronic inflammatory disease of the large intestine that is becoming more common across the world, including among teenagers and young adults. For many patients it begins with subtle warning signs such as abdominal discomfort, diarrhea, fatigue, or traces of blood in the stool. Over time these symptoms can escalate into painful and frightening flare-ups that disrupt education, careers, family life, and emotional well-being. Although modern medicine has become remarkably effective at calming these acute disease episodes, UC remains stubbornly persistent. In most patients the disease returns after periods of apparent recovery, sometimes without any obvious external trigger.

Professor François Vialard  | Unraveling Azoospermia: Using Genetics to Avoid Futile Sperm Extraction

Professor François Vialard | Unraveling Azoospermia: Using Genetics to Avoid Futile Sperm Extraction

For many couples struggling to conceive, a male infertility diagnosis can feel like a closed door. Roughly half of all infertility cases worldwide stem from male factors, and among these, one of the most frustrating conditions is non-obstructive azoospermia (or NOA for short), a complete absence of sperm caused not by a physical blockage but by a failure of sperm production itself. Until recently, most men with NOA were offered a potentially painful and uncertain procedure called testicular sperm extraction (or TESE). In this surgery, doctors search directly within the testis for a few viable sperm cells that can be used for in vitro fertilization. When successful, the results can be life-changing. When unsuccessful, it is physically invasive, emotionally draining, and often repeated several times in vain.

Prof. Jim Oates | When Blood Vessels Speak: How Lupus Turns the Body’s Gatekeepers into Active Messengers of Inflammation

Prof. Jim Oates | When Blood Vessels Speak: How Lupus Turns the Body’s Gatekeepers into Active Messengers of Inflammation

You may imagine your vasculature as a vast and silent network of tubes, dutifully carrying blood, oxygen, and nutrients to every organ and tissue. These vessels seem purely mechanical, like plumbing hidden behind walls, doing their job quietly and invisibly. Yet modern biology has revealed a far richer and more surprising reality. Blood vessels are lined with living, sensing, responding cells called endothelial cells, and these cells are anything but passive. They listen to chemical signals, respond to stress, regulate traffic, and communicate constantly with the immune system.

Prof. Stephen Graham | From Hospitals to Households: How Decentralised Care Is Transforming Tuberculosis Treatment for Children

Prof. Stephen Graham | From Hospitals to Households: How Decentralised Care Is Transforming Tuberculosis Treatment for Children

Tuberculosis remains one of the world’s oldest and most stubborn infectious diseases, yet the way health systems respond to it is often dogged by modern challenges. Clinics are overcrowded, families must travel long distances, and children with vague or non-specific symptoms are frequently overlooked. For decades, tuberculosis care has been organised around hospitals and specialised facilities, even though the disease itself spreads and takes root in homes and communities. A growing body of research now argues that this mismatch is costing lives, particularly among children. Decentralised models of care, which bring services closer to families and empower community-based health workers, offer a compelling alternative. Recent evidence from multiple settings shows that when tuberculosis care is shifted out of distant clinics and into neighbourhoods and households, access expands with potential to close the current gaps in TB detection, treatment outcomes and prevention that benefit communities and families, including their children.