Discovery of Neurotrophic Factor-α1 Reveals New Treatment Strategies for Stress-induced Neurodegenerative Diseases and Depression | Dr Y. Peng Loh
About this episode
Stress produces numerous negative effects on the human body. Lying deep within the brain, one particularly sensitive area is the hippocampus, where chronic exposure to stress hormones can lead to the degeneration and death of neurons. Thankfully, the brain holds defence mechanisms that block some of these negative effects. Deciphering these mechanisms with the aim of better treating neurodegenerative diseases and depression is Dr Y. Peng Loh from the Eunice Kennedy Shriver National Institute of Child Health and Human Development in the USA.
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Dr Samantha Dolan – Investigating Facilitators and Barriers to Electronic Immunisation Registry Implementation in Tanzania and Zambia
Digital health interventions have the potential to revolutionalise the management of health information. Despite reduced costs and increased accessibility of technology across the world, the implementation of digital health technologies in low- and middle-income countries has been less than optimal. Dr Samantha Dolan at PATH and the University of Washington and her colleagues investigated the perceived facilitators and barriers to electronic immunisation registry implementation in Tanzania and Zambia, and provide important recommendations for future practice.
There are over 3,600 established cell lines from 150 different species that can be used for scientific and medical research. In two recent studies, Dr Ruth MacKinnon and her team from St Vincent’s Hospital in Melbourne used multiple molecular methods to investigate changes in the way the genes are organised in two types of these cells. They demonstrated the importance of using multiple complementary methods and found that these cells can continue to evolve in the laboratory. They also uncovered evidence of a previously unreported process called ‘centromere capture’ which may be involved in the evolution of cancer cells.
Weaning is an important time in the pig lifecycle, and changes in diet and environment can lead to unbalanced gut microbiota and pathogen colonisation. Prof. Luciana Rossi, Dr. Matteo Dell’Anno from the University of Milan, and Dr. Maria Luisa Callegari from Catholic University of Sacred Heart, have been investigating the impact on gut bacteria of adding natural compounds known as tannins to piglet food. Importantly, they found that tannins do affect the gut bacteria; with increases seen in bacteria associated with improved growth and gut health, and in particular, those that produce butyrate – a substance with proven health benefits.
Epithelial tissue is a protective layer of cells bound together into thin sheets that coat the internal and external surfaces of major body organs. The largest is the epidermis – the outer layer of the skin. This sheet-like structure is integral to its function and is maintained by a complex scaffolding network called the extracellular matrix (ECM). Dr Jacopo Di Russo and his colleagues at the Interdisciplinary Centre for Clinical Research of the University Hospital of Aachen, Germany, have recently discussed the diverse nature of the ECM and its hugely unmet potential within bioengineering.
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