For decades, the story of tobacco and the heart seemed settled. Cigarettes were dangerous because they burned, releasing tar, carbon monoxide, and thousands of toxic chemicals that wrecked blood vessels. Remove the fire, the thinking went, and you remove almost all of the danger. That’s the logic behind heat-not-burn devices, e-cigarettes, and now nicotine pouches, each marketed, in turn, as the “safer” next step for people who can’t or won’t quit nicotine altogether.

For more than half a century, vaccines have quietly transformed human life. They have prevented suffering on a scale that is difficult to imagine, protecting millions of children from diseases that once claimed countless lives. Many of the most dramatic public health victories of the modern era have been built on vaccination. Diseases that once filled hospitals, overwhelmed families, and devastated communities became rare or disappeared entirely in many parts of the world. Yet vaccination now stands at a fascinating moment in history.

Every second of every day, your heart performs an extraordinary balancing act. Roughly the size of your fist, this remarkable organ contracts about 100,000 times each day, pumping thousands of litres of blood through an intricate network of vessels. It does so with astonishing reliability, rarely taking a break from the moment it first begins beating before birth until the end of life. Most of us think about the heart in simple terms. We measure its rate, check our blood pressure, or perhaps hear about blocked arteries and heart attacks. Doctors often assess how much blood the heart pumps with each beat or calculate the familiar “ejection fraction,” which estimates how well the heart empties during contraction. These measurements are valuable, but they tell only part of the story.

Type 2 diabetes has become one of the defining health challenges of our time. Hundreds of millions of people worldwide are living with the disease, and the numbers continue to climb. While unhealthy diets, reduced physical activity, and increasing rates of obesity have all contributed to this growing epidemic, they tell only part of the story. Genetics also plays an important role, influencing why some people develop diabetes while others remain healthy despite living similar lifestyles.

Im späten neunzehnten Jahrhundert stand die Medizin an der Schwelle zwischen Verzweiflung und Entdeckung. Krebs des Kehlkopfes, jener Struktur, die uns die Stimme verleiht und unsere Atemwege schützt, verlief fast immer tödlich. Chirurgen verfügten nur über wenige Werkzeuge und noch weniger Erfolge. Dann veränderte im Jahr 1873 eine mutige und kontroverse Operation alles. Theodor Billroth führte die erste totale Laryngektomie durch und entfernte einem menschlichen Patienten den gesamten Kehlkopf. Es war ein radikaler Eingriff, der ein Leben rettete – allerdings um den Preis des Sprachvermögens und der natürlichen Atmung. Dieser Moment markierte den Beginn einer langen und sich stetig weiterentwickelnden Reise in der Behandlung von Kopf-Hals-Karzinomen.

For decades, cancer treatment has followed a familiar path. A tumor is found, surgery removes it, radiation burns what remains, and chemotherapy or immunotherapy attempts to destroy cells that may have spread elsewhere. These treatments have saved countless lives, yet they often come with immense physical, emotional, and financial costs. Many patients endure fatigue, pain, scarring, organ damage, mounting bills and lifelong side effects. However, the extraordinary advances of modern medicine have often included the commercial viability of a proven medical product, regardless of its cost and accessibility. The dream of a gentler, more precise, and more effective cancer treatment has remained elusive.

Every healthcare professional involved in the care of patients with chronic obstructive pulmonary disease understands the challenge. COPD is one of the world’s leading causes of illness and death, affecting more than 300 million people and placing an enormous burden on healthcare systems. Although treatment options have improved significantly over recent decades, clinicians continue to face a fundamental problem. They mostly rely on diagnostic measurements that do not fully capture the disease’s complexity. For many years, a simple form of spirometry has been the cornerstone of COPD diagnosis and management. The ratio of forced expiratory volume in one second and forced vital capacity is relatively easy and inexpensive to measure. It is therefore widely available and is supported by decades of clinical experience. This ratio has become so firmly established as a measure of the disease that it is virtually impossible to imagine COPD assessment without it.