Understanding Why Obesity is a Risk Factor for Cancer | Dr Aliccia Bollig-Fischer
About this episode
Cancer can be caused by genetic mutations or epigenetic alterations, which are changes to the way DNA is processed, rather than to the DNA itself. These changes can be brought about by obesity, and more specifically, oxidative stress and consequent reactive oxygen species. However, the molecular mechanisms by which this occurs are not well understood. Dr Aliccia Bollig-Fischer from Wayne State University School of Medicine in Michigan is studying these processes and paving the way for the development of novel cancer therapeutics.
This work is licensed under a Creative Commons Attribution 4.0 International License.
What does this mean?
Share: You can copy and redistribute the material in any medium or format
Adapt: You can change, and build upon the material for any purpose, even commercially.
Credit: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
Most human diseases are localised in terms of their location but currently, injected or orally administered drugs are evenly distributed all over the body and thus, act indiscriminately. The targeted delivery of medication to the exact site where it is needed is a common theme in science fiction but thanks to Professor Richard Klemke and his team at the University of California San Diego’s Moores Cancer Center, this fantasy may soon become a reality.
Professor Michael Bukrinsky | Human Immunodeficiency Virus Co-morbidities: How Lipid Homeostasis Alterations Lead to Cardiovascular and Neurological Disorders
Although human immunodeficiency virus (HIV) is still prevalent worldwide, life-saving antiretroviral drugs can now prevent an infection from progressing into acquired immunodeficiency syndrome (AIDS). Nevertheless, people who are HIV-positive are still at increased risk of developing neurological disorders and cardiovascular diseases, known as co-morbidities. Professor Michael Bukrinsky from the George Washington University in Washington DC works to understand the underlying biological mechanisms that lead to these disorders. His research has produced interesting results that demonstrate the role of altered lipid (cholesterol) homeostasis in HIV-infected cells and how this comes to pass.
Dr Doug Brugge | The Community Assessment of Freeway Exposure and Health Studies: Minimising Exposure to Traffic-related Air Pollution
Epilepsy is a chronic, long-term disease in which abnormal activity in the brain leads to repeated seizures, and it affects nearly 70 million people worldwide. The exact mechanisms behind epileptic seizures are still poorly understood. However, we do know that epilepsy can be caused by changes in the network structure of our brains and that seizures may be a result of spontaneous excessive brain synchronisation. Professor Eckehard Schöll and his Master student Moritz Gerster together with colleagues are using computer simulations to better understand the interplay of network structure and network synchronisation in epilepsy.
Professor Eckehard Schöll | Moritz Gerster – Rewiring the Brain: How a Small-world Network Structure Mimics Spontaneous Synchronisation in Epileptic Seizures
Increase the impact of your research
• Good science communication helps people make informed decisions and motivates them to take appropriate and affirmative action.
• Good science communication encourages everyday people to be scientifically literate so that they can analyse the integrity and legitimacy of information.
• Good science communication encourages people into STEM-related fields of study and employment.
• Good public science communication fosters a community around research that includes both members of the public, policymakers and scientists.
• In a recent survey, 75% of people suggested they would prefer to listen to an interesting story than read it.
Step 1 Upload your science paper
Step 2 SciPod script written
Step 3 Voice audio recorded
Step 4 SciPod published