When a peripheral nerve is badly damaged due to injury, the consequences can be life-changing. Hands that no longer feel heat or cold, muscles that will not respond to the brain’s commands, and pain that lingers for years are all common outcomes. Surgeons can sometimes stitch nerves back together, but when there is a section of nerve missing entirely, repair becomes far more complex. For decades, researchers have been trying to build better bridges for injured nerve axons to cross. A new interdisciplinary research effort led by Dr. Jeddah Marie Vasquez and Dr. Vijay Kumar Kuna of Research Institutes of Sweden, and their collaborators from Umeå University (Associate Professor Paul Kingham) and University College London (Professor James Phillips), bring together polymer chemistry, materials science, and cell biology to rethink what such a bridge could be made of – and how it might one day be tailored to individual patients.

Ulcerative colitis, often called UC, is a chronic inflammatory disease of the large intestine that is becoming more common across the world, including among teenagers and young adults. For many patients it begins with subtle warning signs such as abdominal discomfort, diarrhea, fatigue, or traces of blood in the stool. Over time these symptoms can escalate into painful and frightening flare-ups that disrupt education, careers, family life, and emotional well-being. Although modern medicine has become remarkably effective at calming these acute disease episodes, UC remains stubbornly persistent. In most patients the disease returns after periods of apparent recovery, sometimes without any obvious external trigger.