How Memories Are Made And Lost In The Brain – Professor Don Kulasiri, Lincoln University

Mar 13, 2020 | biology, trending

Original Article Reference

This SciPod is a summary of the papers ‘Modelling the dynamics of CaMKII–NMDAR complex related to memory formation in synapses: The possible roles of threonine 286 autophosphorylation of CaMKII in long term potentiation’, published in the Journal of Theoretical Biology, DOI:10.1016/j.jtbi.2014.11.001; ‘Modelling bidirectional modulations in synaptic plasticity: A biochemical pathway model to understand the emergence of long term potentiation (LTP) and long term depression (LTD)’, published in the Journal of Theoretical Biology, DOI:10.1016/j.jtbi.2016.05.015; and ‘Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer’s disease’, published in the journal PLOS ONE, DOI:10.1371/journal.pone.0182743.

About this episode

Our brain forms long-term memories and stores information through synaptic plasticity, the ability of the connections between neurons to be strengthened or weakened over time. However, the exact methods through which synaptic plasticity is achieved by the brain remain largely unknown in the scientific community. Professor Don Kulasiri at Lincoln University, New Zealand, is using a mathematical modelling approach to shed light into this process. His findings are providing molecular insights into how memories can be strengthened or lost.






This work is licensed under a Creative Commons Attribution 4.0 International LicenseCreative Commons License

What does this mean?

Share: You can copy and redistribute the material in any medium or format

Adapt: You can change, and build upon the material for any purpose, even commercially.

Credit: You must give appropriate credit, provide a link to the license, and indicate if changes were made.

Increase the impact of your research

• Good science communication helps people make informed decisions and motivates them to take appropriate and affirmative action. • Good science communication encourages everyday people to be scientifically literate so that they can analyse the integrity and legitimacy of information. • Good science communication encourages people into STEM-related fields of study and employment. • Good public science communication fosters a community around research that includes both members of the public, policymakers and scientists. • In a recent survey, 75% of people suggested they would prefer to listen to an interesting story than read it.


 Step 1 Upload your science paper

Step 2 SciPod script written

Step 3 Voice audio recorded

Step 4 SciPod published