Investigating Fructans to Understand How Plants Can Survive Harsh Environments | Dr José Ordaz-Ortiz

Investigating Fructans to Understand How Plants Can Survive Harsh Environments | Dr José Ordaz-Ortiz

The molecules within plant tissues can tell us about how they can withstand harsh environmental conditions. The Agave tequilana plant, native to Mexico, has a high concentration of fructan molecules throughout its tissues. Alongside his colleagues, Dr José Ordaz-Ortiz at the Center for Research and Advanced Studies of the National Polytechnic Institute in Mexico, combines several powerful analytical techniques to better understand the role that these fructans play in plant biology.

Understanding Sudden Unexpected Infant Death: A Unique Collaboration

Understanding Sudden Unexpected Infant Death: A Unique Collaboration

When a supposedly healthy infant passes away, it can be hard to understand why. Juan Lavista Ferres (Microsoft), Dr Jan-Marino Ramirez and Dr Tatiana Anderson (both from Seattle Children’s Research Institute), and Professor Edwin Mitchell (University of Auckland), form the core of a novel collaboration to conduct vital and extensive research into the risk factors and mechanisms behind sudden unexpected infant death. This unique collaboration spanning across disciplines, industries and continents, is providing the deeper understanding that is needed to prevent unnecessary infant deaths.

Return of Baird’s Tapir: Blessing or Omen? | Dr LaRoy Brandt – Maggie Singleton

Return of Baird’s Tapir: Blessing or Omen? | Dr LaRoy Brandt – Maggie Singleton

The destruction of jungle and forest habitats is a serious issue threatening species across the globe. Dr LaRoy Brandt and Maggie Singleton of Lincoln Memorial University studied one such threatened species, Baird’s tapir, in Costa Rica. By identifying the tapir’s tracks and deploying remote trail cameras, the team caught rare glimpses of this threatened species, indicating a return of the native population and an increase in their numbers. The question is, however, is this increase a sign of improving habitats or a result of less favourable forces at play?

How Cancer Cells Overcome the Obstacle of Senescence | Sebastian Igelmann

How Cancer Cells Overcome the Obstacle of Senescence | Sebastian Igelmann

Cellular senescence [suh-NEH-Sns] is the process by which cells age and permanently stop dividing but do not die. While the process of senescence creates a barrier to tumour formation, it can still be overcome by cancer cells. Sebastian Igelmann, a PhD student supervised by group leader Dr Gerardo Ferbeyre at the University of Montreal, has identified a group of enzymes that work together to reprogramme cellular metabolism. This work provides important insight into how tumour cells may initiate proliferation and circumvent senescence. Critically, this specialist group of enzymes provides a potential therapeutic target for human cancer treatment.

The Holy Grail of Safer Opioids: Targeting Mu Opioid Receptor Splice Variants | Dr Ying-Xian Pan

The Holy Grail of Safer Opioids: Targeting Mu Opioid Receptor Splice Variants | Dr Ying-Xian Pan

Despite their numerous side effects, opioid drugs and morphine-like agents have remained a pillar in the medical management of pain. Most clinically used opioid drugs act through mu opioid receptors. Dr Ying-Xian Pan and his team from the Rutgers New Jersey Medical School, USA, studies the molecular and cellular mechanisms of mu opioid receptors and aim to develop novel strategies and opioid analgesics for better treating pain without side effects associated with traditional opiates. Efforts to find substitutes for traditional opioid drugs are helping address the opiate abuse crisis that affects many countries around the globe.

Using Genetics to Diagnose Rare Metabolic Diseases | Dr Michael Wanger

Using Genetics to Diagnose Rare Metabolic Diseases | Dr Michael Wanger

Identifying the cause of an illness in a sick baby or child is not always easy, particularly if the disease is rare. Throughout his career, Dr Michael Wangler, at the Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, has investigated rare childhood diseases. Combining his expertise in paediatrics and genetics, Dr Wangler utilises genomics, metabolomics and the humble fruit fly to identify the genes responsible for rare and undiagnosed diseases to improve both diagnosis and treatment.