Dr Ruth MacKinnon – Genome Organisation and Centromeres and the Evolution of Cancerous Cell Lines

Dr Ruth MacKinnon – Genome Organisation and Centromeres and the Evolution of Cancerous Cell Lines

There are over 3,600 established cell lines from 150 different species that can be used for scientific and medical research. In two recent studies, Dr Ruth MacKinnon and her team from St Vincent’s Hospital in Melbourne used multiple molecular methods to investigate changes in the way the genes are organised in two types of these cells. They demonstrated the importance of using multiple complementary methods and found that these cells can continue to evolve in the laboratory. They also uncovered evidence of a previously unreported process called ‘centromere capture’ which may be involved in the evolution of cancer cells.

Investigating the Impact of Tannins on Gut Bacteria in Pigs

Investigating the Impact of Tannins on Gut Bacteria in Pigs

Weaning is an important time in the pig lifecycle, and changes in diet and environment can lead to unbalanced gut microbiota and pathogen colonisation. Prof. Luciana Rossi, Dr. Matteo Dell’Anno from the University of Milan, and Dr. Maria Luisa Callegari from Catholic University of Sacred Heart, have been investigating the impact on gut bacteria of adding natural compounds known as tannins to piglet food. Importantly, they found that tannins do affect the gut bacteria; with increases seen in bacteria associated with improved growth and gut health, and in particular, those that produce butyrate – a substance with proven health benefits.

Dr Jacopo Di Russo – Understanding the Complexity of Epithelia

Dr Jacopo Di Russo – Understanding the Complexity of Epithelia

Epithelial tissue is a protective layer of cells bound together into thin sheets that coat the internal and external surfaces of major body organs. The largest is the epidermis – the outer layer of the skin. This sheet-like structure is integral to its function and is maintained by a complex scaffolding network called the extracellular matrix (ECM). Dr Jacopo Di Russo and his colleagues at the Interdisciplinary Centre for Clinical Research of the University Hospital of Aachen, Germany, have recently discussed the diverse nature of the ECM and its hugely unmet potential within bioengineering.

Dr Ben Jones – Key Advances in Measuring the Effect of Training in Competitive Swimmers

Dr Ben Jones – Key Advances in Measuring the Effect of Training in Competitive Swimmers

Swimming was one of the nine original Olympic sports in 1896, and to this day, remains one of the most popular competitive and recreational sports. However, methods to track the effect of training programmes and physiological changes in swimmers have lagged behind those of other sports due to difficulties caused by the aquatic environment. Dr Ben Jones and his team from the University of Essex have used a novel underwater near infrared spectrometer to monitor the effects of a training programme on muscle oxygenation in teenage swimmers.

The 2022 Prince Mahidol Award Conference: Building the World We Want

The 2022 Prince Mahidol Award Conference: Building the World We Want

Humanity is facing many challenges, ranging from COVID-19 to climate change, and from natural resource depletion to social inequity. The Prince Mahidol Award Conference is an annual event held in Bangkok, where leaders and experts meet to discuss global challenges. This year, the theme was ‘The World We Want: Actions Towards a Sustainable, Fairer and Healthier Society’.

Effects of DNA Repair Mechanisms, Oestrogen and Environmental Chemicals on Risk for Breast Cancer | Dr Joseph Jerry

Effects of DNA Repair Mechanisms, Oestrogen and Environmental Chemicals on Risk for Breast Cancer | Dr Joseph Jerry

All women are exposed to oestrogen from puberty through menopause. Oestrogen is a natural hormone that is important for breast development and the maintenance of tissues in women but is also linked to an increased risk of breast cancer. As many as 1 in 8 women in the USA will be diagnosed with breast cancer over their lifetime, and the majority of these breast cancers are sensitive to oestrogen. Dr Joseph Jerry and his collaborators at the University of Massachusetts are studying the environmental exposures and genetic differences that alter the consequences of exposure to oestrogens.